Detailed information of TA system TA107772

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 7800..8042
• Replicon: plasmid unnamed3
• Accession: NZ_CP030339
• Organism: Escherichia coli strain AR_451

Toxin (Protein)

• Gene name: hok
• Uniprot ID: P11895
• Locus tag: CSC38_RS26685
• Protein ID: WP_001312861.1
• Coordinates: 7800..7958 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	8002..8042 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC38_RS26640	2912..3139	-	228	WP_001254388.1	conjugal transfer relaxosome protein TraY	-
CSC38_RS26645	3227..3904	-	678	WP_001348626.1	PAS domain-containing protein	-
CSC38_RS26650	4038..4421	-	384	WP_001151566.1	relaxosome protein TraM	-
CSC38_RS26655	4752..5354	+	603	WP_000243712.1	transglycosylase SLT domain-containing protein	-
CSC38_RS26660	5651..6472	-	822	WP_001234469.1	DUF945 domain-containing protein	-
CSC38_RS26665	6591..6878	-	288	WP_000107535.1	hypothetical protein	-
CSC38_RS27425	6903..7109	-	207	WP_000275859.1	hypothetical protein	-
CSC38_RS27430	7022..7357	-	336	WP_013023876.1	hypothetical protein	-
CSC38_RS26685	7800..7958	-	159	WP_001312861.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	8002..8042	-	41	NuclAT_1	-	Antitoxin
-	8002..8042	-	41	NuclAT_1	-	Antitoxin
-	8002..8042	-	41	NuclAT_1	-	Antitoxin
-	8002..8042	-	41	NuclAT_1	-	Antitoxin
-	9486..9672	-	187	NuclAT_0	-	-
-	9486..9672	-	187	NuclAT_0	-	-
-	9486..9672	-	187	NuclAT_0	-	-
-	9486..9672	-	187	NuclAT_0	-	-
CSC38_RS26695	9684..10403	-	720	WP_001276232.1	plasmid SOS inhibition protein A	-
CSC38_RS26700	10400..10834	-	435	WP_000845940.1	conjugation system SOS inhibitor PsiB	-
CSC38_RS26705	10889..12846	-	1958	Protein_19	ParB/RepB/Spo0J family partition protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..35509	35509

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6082.32 Da
• Isoelectric Point: 9.2584

>T107772 WP_001312861.1 NZ_CP030339:c7958-7800 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T107772 NZ_CP030339:c7958-7800 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Nucleotide

• Length: 41 bp

>AT107772 NZ_CP030339:c8042-8002 [Escherichia coli]
TTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Toxin

• AlphaFold DB: P11895

Antitoxin