Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2591985..2592169 Replicon chromosome
Accession NZ_CP030326
Organism Staphylococcus aureus strain AR_474

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag CSC59_RS13920 Protein ID WP_000482652.1
Coordinates 2592062..2592169 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2591985..2592045 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC59_RS13895 2587440..2587607 - 168 Protein_2537 hypothetical protein -
CSC59_RS13905 2587838..2589571 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
CSC59_RS13910 2589596..2591359 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2591985..2592045 + 61 - - Antitoxin
CSC59_RS13920 2592062..2592169 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
CSC59_RS13925 2592303..2592689 - 387 WP_000779360.1 flippase GtxA -
CSC59_RS13930 2592957..2594099 + 1143 WP_001176863.1 glycerate kinase -
CSC59_RS13935 2594159..2594818 + 660 WP_000831298.1 membrane protein -
CSC59_RS13940 2595000..2596211 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
CSC59_RS13945 2596334..2596807 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T107703 WP_000482652.1 NZ_CP030326:c2592169-2592062 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T107703 NZ_CP030326:c2592169-2592062 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT107703 NZ_CP030326:2591985-2592045 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References