Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2305407..2305623 Replicon chromosome
Accession NZ_CP030326
Organism Staphylococcus aureus strain AR_474

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag CSC59_RS12350 Protein ID WP_001802298.1
Coordinates 2305519..2305623 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2305407..2305462 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC59_RS12330 2301613..2302278 - 666 WP_001024095.1 SDR family oxidoreductase -
CSC59_RS12335 2302430..2302750 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
CSC59_RS12340 2302752..2303729 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
CSC59_RS12345 2303995..2305086 + 1092 WP_000495669.1 hypothetical protein -
- 2305407..2305462 + 56 - - Antitoxin
CSC59_RS12350 2305519..2305623 - 105 WP_001802298.1 hypothetical protein Toxin
CSC59_RS12360 2306303..2306461 + 159 WP_001792784.1 hypothetical protein -
CSC59_RS12370 2307119..2307976 - 858 WP_000370923.1 Cof-type HAD-IIB family hydrolase -
CSC59_RS12375 2308044..2308826 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T107701 WP_001802298.1 NZ_CP030326:c2305623-2305519 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T107701 NZ_CP030326:c2305623-2305519 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT107701 NZ_CP030326:2305407-2305462 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References