Detailed information of TA system TA107697

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2133756..2134055
• Replicon: chromosome
• Accession: NZ_CP030326
• Organism: Staphylococcus aureus strain AR_474

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC59_RS11355
• Protein ID: WP_011447039.1
• Coordinates: 2133879..2134055 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2133756..2133811 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC59_RS11305	2129087..2129347	+	261	WP_001791826.1	hypothetical protein	-
CSC59_RS11310	2129400..2129750	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSC59_RS11315	2130435..2130884	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSC59_RS11320	2130979..2131314	-	336	Protein_2062	SH3 domain-containing protein	-
CSC59_RS11335	2131964..2132455	-	492	WP_000919350.1	staphylokinase	-
CSC59_RS11340	2132646..2133401	-	756	WP_000861038.1	CHAP domain-containing protein	-
CSC59_RS11345	2133413..2133667	-	255	WP_000611512.1	phage holin	-
CSC59_RS11350	2133719..2133826	+	108	WP_001791821.1	hypothetical protein	-
-	2133748..2133887	+	140	NuclAT_0	-	-
-	2133748..2133887	+	140	NuclAT_0	-	-
-	2133748..2133887	+	140	NuclAT_0	-	-
-	2133748..2133887	+	140	NuclAT_0	-	-
-	2133756..2133811	+	56	-	-	Antitoxin
CSC59_RS11355	2133879..2134055	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSC59_RS11360	2134205..2134501	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSC59_RS11365	2134559..2134846	-	288	WP_001040261.1	hypothetical protein	-
CSC59_RS11370	2134893..2135045	-	153	WP_001153681.1	hypothetical protein	-
CSC59_RS11375	2135035..2138820	-	3786	WP_000582154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2129400..2182918	53518

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T107697 WP_011447039.1 NZ_CP030326:c2134055-2133879 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T107697 NZ_CP030326:c2134055-2133879 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT107697 NZ_CP030326:2133756-2133811 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin