Detailed information of TA system TA107690

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1080865..1081444
• Replicon: chromosome
• Accession: NZ_CP030326
• Organism: Staphylococcus aureus strain AR_474

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CSC59_RS05805
• Protein ID: WP_001025401.1
• Coordinates: 1080865..1081110 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1081079..1081444 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC59_RS05760	1076883..1077497	+	615	WP_000191459.1	hypothetical protein	-
CSC59_RS05765	1077494..1077640	-	147	WP_001013104.1	hypothetical protein	-
CSC59_RS05770	1077870..1078454	-	585	WP_000825948.1	hypothetical protein	-
CSC59_RS05775	1078472..1078933	-	462	WP_000525004.1	hypothetical protein	-
CSC59_RS05780	1078946..1079260	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
CSC59_RS05785	1079412..1079648	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
CSC59_RS05790	1079662..1080438	+	777	WP_001148544.1	Rha family transcriptional regulator	-
CSC59_RS05795	1080467..1080610	+	144	WP_000939498.1	hypothetical protein	-
CSC59_RS05800	1080600..1080809	-	210	WP_000642492.1	hypothetical protein	-
CSC59_RS05805	1080865..1081110	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CSC59_RS05810	1081079..1081444	-	366	WP_001128433.1	hypothetical protein	Antitoxin
CSC59_RS05815	1081499..1081714	+	216	WP_001097552.1	hypothetical protein	-
CSC59_RS05820	1081739..1082002	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
CSC59_RS05825	1082015..1082176	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
CSC59_RS05830	1082255..1082578	+	324	WP_000175002.1	hypothetical protein	-
CSC59_RS05835	1082593..1082955	+	363	WP_000985976.1	hypothetical protein	-
CSC59_RS05840	1082952..1084118	+	1167	WP_000762547.1	DUF2800 domain-containing protein	-
CSC59_RS05845	1084144..1084701	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1075552..1120425	44873

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T107690 WP_001025401.1 NZ_CP030326:1080865-1081110 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T107690 NZ_CP030326:1080865-1081110 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT107690 NZ_CP030326:c1081444-1081079 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin