Detailed information of TA system TA107682

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1818427..1818765
• Replicon: chromosome
• Accession: NZ_CP030323
• Organism: Staphylococcus aureus strain AR_475

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC60_RS09310
• Protein ID: WP_011447039.1
• Coordinates: 1818427..1818603 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1818591..1818765 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC60_RS09290	1813662..1817447	+	3786	WP_000582158.1	hypothetical protein	-
CSC60_RS09295	1817437..1817589	+	153	WP_001153681.1	hypothetical protein	-
CSC60_RS09300	1817636..1817923	+	288	WP_001040261.1	hypothetical protein	-
CSC60_RS09305	1817981..1818277	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSC60_RS09310	1818427..1818603	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	1818591..1818765	-	175	-	-	Antitoxin
CSC60_RS09320	1818815..1819069	+	255	WP_000611512.1	phage holin	-
CSC60_RS09325	1819081..1819836	+	756	WP_000861038.1	CHAP domain-containing protein	-
CSC60_RS09330	1820027..1820518	+	492	WP_000919350.1	staphylokinase	-
CSC60_RS09340	1821168..1821503	+	336	Protein_1730	SH3 domain-containing protein	-
CSC60_RS09345	1821598..1822047	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSC60_RS09350	1822728..1823078	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
CSC60_RS09355	1823131..1823391	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1768068..1823078	55010

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T107682 WP_011447039.1 NZ_CP030323:1818427-1818603 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T107682 NZ_CP030323:1818427-1818603 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT107682 NZ_CP030323:c1818765-1818591 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin