Detailed information of TA system TA107681

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1795363..1795777
• Replicon: chromosome
• Accession: NZ_CP030323
• Organism: Staphylococcus aureus strain AR_475

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CSC60_RS09170
• Protein ID: WP_001065046.1
• Coordinates: 1795363..1795614 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CSC60_RS14475
• Protein ID: WP_000028424.1
• Coordinates: 1795604..1795777 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC60_RS09130	1791089..1792009	+	921	WP_031764964.1	recombinase RecT	-
CSC60_RS09135	1792090..1792698	+	609	WP_078090917.1	MBL fold metallo-hydrolase	-
CSC60_RS09140	1792699..1793169	+	471	WP_000610649.1	single-stranded DNA-binding protein	-
CSC60_RS09145	1793199..1794083	+	885	WP_000148302.1	DnaD domain protein	-
CSC60_RS09150	1794090..1794308	+	219	WP_000338528.1	hypothetical protein	-
CSC60_RS09155	1794317..1794721	+	405	WP_000401963.1	RusA family crossover junction endodeoxyribonuclease	-
CSC60_RS09160	1794734..1795102	+	369	WP_000101275.1	hypothetical protein	-
CSC60_RS09165	1795106..1795348	+	243	WP_000131381.1	phi PVL orf 51-like protein	-
CSC60_RS09170	1795363..1795614	+	252	WP_001065046.1	DUF1024 family protein	Toxin
CSC60_RS14475	1795604..1795777	+	174	WP_000028424.1	hypothetical protein	Antitoxin
CSC60_RS09175	1795803..1796060	+	258	Protein_1696	hypothetical protein	-
CSC60_RS14480	1796061..1796222	+	162	WP_000889682.1	hypothetical protein	-
CSC60_RS09180	1796237..1796770	+	534	WP_001061844.1	dUTP diphosphatase	-
CSC60_RS09185	1796807..1797013	+	207	WP_000195810.1	DUF1381 domain-containing protein	-
CSC60_RS09190	1797010..1797159	+	150	WP_000595267.1	hypothetical protein	-
CSC60_RS09195	1797318..1797968	+	651	WP_001005262.1	hypothetical protein	-
CSC60_RS09200	1797968..1798168	+	201	WP_000265041.1	DUF1514 family protein	-
CSC60_RS09205	1798196..1798612	+	417	WP_000590126.1	hypothetical protein	-
CSC60_RS09210	1798844..1799143	+	300	WP_000988336.1	HNH endonuclease	-
CSC60_RS09215	1799274..1799618	+	345	WP_000402904.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1768068..1823078	55010

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9377.26 Da
• Isoelectric Point: 3.7128

>T107681 WP_001065046.1 NZ_CP030323:1795363-1795614 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T107681 NZ_CP030323:1795363-1795614 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT107681 WP_000028424.1 NZ_CP030323:1795604-1795777 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT107681 NZ_CP030323:1795604-1795777 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA