Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 853706..854223 Replicon chromosome
Accession NZ_CP030323
Organism Staphylococcus aureus strain AR_475

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag CSC60_RS04140 Protein ID WP_000113263.1
Coordinates 853957..854223 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CSC60_RS04135 Protein ID WP_000584499.1
Coordinates 853706..853957 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC60_RS04105 849406..850125 + 720 WP_000479576.1 amino acid ABC transporter permease -
CSC60_RS04110 850122..850853 + 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
CSC60_RS04115 850950..852200 - 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
CSC60_RS04120 852455..852817 + 363 WP_000819839.1 DUF4467 domain-containing protein -
CSC60_RS04125 852836..853435 + 600 WP_000162810.1 DsbA family protein -
CSC60_RS04130 853442..853533 + 92 Protein_781 hypothetical protein -
CSC60_RS04135 853706..853957 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSC60_RS04140 853957..854223 + 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
CSC60_RS04145 854517..856064 + 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CSC60_RS04150 856250..856717 + 468 WP_000153338.1 SRPBCC domain-containing protein -
CSC60_RS04155 856804..856986 + 183 WP_000079140.1 hypothetical protein -
CSC60_RS04160 857190..858014 + 825 WP_000594633.1 formate/nitrite transporter family protein -
CSC60_RS04165 858427..858963 + 537 WP_000185901.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T107673 WP_000113263.1 NZ_CP030323:853957-854223 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T107673 NZ_CP030323:853957-854223 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT107673 WP_000584499.1 NZ_CP030323:853706-853957 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT107673 NZ_CP030323:853706-853957 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References