Detailed information of TA system TA107585

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 71208..71472
• Replicon: plasmid p205880-5
• Accession: NZ_CP030307
• Organism: Klebsiella pneumoniae strain 205880

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: -
• Locus tag: DRB04_RS28940
• Protein ID: WP_024179505.1
• Coordinates: 71208..71360 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	71412..71472 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DRB04_RS28920 (68040)	68040..68702	+	663	WP_060527638.1	plasmid IncI1-type surface exclusion protein ExcA	-
DRB04_RS28925 (68774)	68774..68983	-	210	WP_000062603.1	HEAT repeat domain-containing protein	-
DRB04_RS28930 (69376)	69376..69552	+	177	WP_180335155.1	hypothetical protein	-
- (70441)	70441..70492	+	52	NuclAT_1	-	-
- (70441)	70441..70492	+	52	NuclAT_1	-	-
- (70441)	70441..70492	+	52	NuclAT_1	-	-
- (70441)	70441..70492	+	52	NuclAT_1	-	-
DRB04_RS28935 (70885)	70885..71136	+	252	WP_001291962.1	hypothetical protein	-
DRB04_RS28940 (71208)	71208..71360	-	153	WP_024179505.1	Hok/Gef family protein	Toxin
- (71412)	71412..71472	+	61	NuclAT_0	-	Antitoxin
- (71412)	71412..71472	+	61	NuclAT_0	-	Antitoxin
- (71412)	71412..71472	+	61	NuclAT_0	-	Antitoxin
- (71412)	71412..71472	+	61	NuclAT_0	-	Antitoxin
DRB04_RS28945 (71652)	71652..72860	+	1209	WP_064148469.1	IncI1-type conjugal transfer protein TrbA	-
DRB04_RS28950 (72879)	72879..73949	+	1071	WP_064148470.1	IncI1-type conjugal transfer protein TrbB	-
DRB04_RS28955 (73942)	73942..76233	+	2292	WP_077265944.1	F-type conjugative transfer protein TrbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..82822	82822

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5743.07 Da
• Isoelectric Point: 8.7948

>T107585 WP_024179505.1 NZ_CP030307:c71360-71208 [Klebsiella pneumoniae]
MPQRTFLMMLIVVCVTILCFVWIVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T107585 NZ_CP030307:c71360-71208 [Klebsiella pneumoniae]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATTGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT107585 NZ_CP030307:71412-71472 [Klebsiella pneumoniae]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Antitoxin