Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 113001..113254 | Replicon | plasmid p283747-1 |
Accession | NZ_CP030301 | ||
Organism | Klebsiella pneumoniae strain 283747 |
Toxin (Protein)
Gene name | srnB | Uniprot ID | G9G1E3 |
Locus tag | DRB02_RS27860 | Protein ID | WP_001312851.1 |
Coordinates | 113001..113150 (-) | Length | 50 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 113195..113254 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DRB02_RS27825 (108360) | 108360..108775 | - | 416 | Protein_150 | IS1-like element IS1B family transposase | - |
DRB02_RS27830 (109024) | 109024..109425 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
DRB02_RS27835 (109358) | 109358..109615 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
DRB02_RS27840 (109708) | 109708..110361 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
DRB02_RS27845 (111300) | 111300..112157 | - | 858 | WP_032495102.1 | incFII family plasmid replication initiator RepA | - |
DRB02_RS28340 (112176) | 112176..112354 | - | 179 | Protein_155 | protein CopA/IncA | - |
DRB02_RS27855 (112469) | 112469..112717 | - | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
DRB02_RS27860 (113001) | 113001..113150 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
- (113195) | 113195..113254 | + | 60 | NuclAT_1 | - | Antitoxin |
- (113195) | 113195..113254 | + | 60 | NuclAT_1 | - | Antitoxin |
- (113195) | 113195..113254 | + | 60 | NuclAT_1 | - | Antitoxin |
- (113195) | 113195..113254 | + | 60 | NuclAT_1 | - | Antitoxin |
DRB02_RS27865 (113455) | 113455..113787 | - | 333 | WP_152916585.1 | hypothetical protein | - |
DRB02_RS27870 (113849) | 113849..114448 | - | 600 | WP_032083981.1 | PIN domain-containing protein | - |
DRB02_RS27875 (114834) | 114834..115034 | - | 201 | WP_015059022.1 | hypothetical protein | - |
DRB02_RS27880 (115166) | 115166..115726 | - | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
DRB02_RS27885 (115781) | 115781..116527 | - | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
DRB02_RS27890 (116547) | 116547..116747 | - | 201 | WP_072354025.1 | hypothetical protein | - |
DRB02_RS27895 (116772) | 116772..117476 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
DRB02_RS27900 (117529) | 117529..117594 | + | 66 | Protein_165 | helix-turn-helix domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | blaKPC-2 / blaSHV-12 / rmtB / blaTEM-1B / fosA3 / blaCTX-M-65 | - | 1..148021 | 148021 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T107557 WP_001312851.1 NZ_CP030301:c113150-113001 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T107557 NZ_CP030301:c113150-113001 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 60 bp
>AT107557 NZ_CP030301:113195-113254 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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