Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 69341..69594 Replicon plasmid p309074-2
Accession NZ_CP030298
Organism Klebsiella pneumoniae strain 309074

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag DQG43_RS27205 Protein ID WP_001312851.1
Coordinates 69445..69594 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 69341..69400 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQG43_RS27170 (65117) 65117..65977 + 861 WP_000704523.1 alpha/beta hydrolase -
DQG43_RS27175 (66080) 66080..66640 + 561 WP_000139321.1 fertility inhibition protein FinO -
DQG43_RS27180 (66769) 66769..66981 + 213 WP_001309245.1 ANR family transcriptional regulator -
DQG43_RS27185 (67226) 67226..67687 + 462 WP_001233838.1 thermonuclease family protein -
DQG43_RS27190 (67733) 67733..67942 + 210 WP_001298565.1 hemolysin expression modulator Hha -
DQG43_RS27195 (67980) 67980..68570 + 591 WP_033807967.1 DUF2726 domain-containing protein -
DQG43_RS27200 (68725) 68725..69198 + 474 WP_016240489.1 hypothetical protein -
- (69341) 69341..69400 - 60 NuclAT_1 - Antitoxin
- (69341) 69341..69400 - 60 NuclAT_1 - Antitoxin
- (69341) 69341..69400 - 60 NuclAT_1 - Antitoxin
- (69341) 69341..69400 - 60 NuclAT_1 - Antitoxin
DQG43_RS27205 (69445) 69445..69594 + 150 WP_001312851.1 Hok/Gef family protein Toxin
DQG43_RS27210 (69879) 69879..70127 + 249 WP_000083839.1 replication regulatory protein RepA -
DQG43_RS27770 (70242) 70242..70426 + 185 Protein_92 protein CopA/IncA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..70438 70438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T107534 WP_001312851.1 NZ_CP030298:69445-69594 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

>T107534 NZ_CP030298:69445-69594 [Klebsiella pneumoniae]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 60 bp

>AT107534 NZ_CP030298:c69400-69341 [Klebsiella pneumoniae]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References