107490

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 743873..744648 Replicon chromosome
Accession NZ_CP030292
Organism Klebsiella pneumoniae strain 721005

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag DRB00_RS03715 Protein ID WP_004150910.1
Coordinates 744163..744648 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag DRB00_RS03710 Protein ID WP_004150912.1
Coordinates 743873..744166 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRB00_RS03690 (DRB00_03825) 739081..739683 - 603 WP_002916735.1 short chain dehydrogenase -
DRB00_RS03695 (DRB00_03830) 739781..740692 + 912 WP_004188550.1 LysR family transcriptional regulator -
DRB00_RS03700 (DRB00_03835) 740693..741841 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
DRB00_RS03705 (DRB00_03840) 741852..743228 - 1377 WP_004217775.1 cystathionine beta-synthase -
DRB00_RS03710 (DRB00_03845) 743873..744166 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
DRB00_RS03715 (DRB00_03850) 744163..744648 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
DRB00_RS03720 (DRB00_03855) 745352..745945 + 594 WP_004188553.1 hypothetical protein -
DRB00_RS03725 (DRB00_03860) 746042..746258 + 217 Protein_733 transposase -
DRB00_RS03730 (DRB00_03875) 746864..747736 + 873 WP_004188557.1 ParA family protein -
DRB00_RS03735 (DRB00_03880) 747736..748119 + 384 WP_004150906.1 hypothetical protein -
DRB00_RS03740 (DRB00_03885) 748112..749479 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 746042..746194 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T107490 WP_004150910.1 NZ_CP030292:744163-744648 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T107490 NZ_CP030292:744163-744648 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT107490 WP_004150912.1 NZ_CP030292:743873-744166 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT107490 NZ_CP030292:743873-744166 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References