Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4626638..4627300 Replicon chromosome
Accession NZ_CP030265
Organism Skermanella pratensis strain W17

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag DPR14_RS21300 Protein ID WP_158046934.1
Coordinates 4627019..4627300 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DPR14_RS21295 Protein ID WP_211104064.1
Coordinates 4626638..4626928 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPR14_RS21270 4622203..4622811 - 609 WP_158046928.1 hypothetical protein -
DPR14_RS21275 4622811..4624724 - 1914 WP_158046929.1 hypothetical protein -
DPR14_RS21280 4624721..4625293 - 573 WP_158046930.1 hypothetical protein -
DPR14_RS21285 4625324..4625593 - 270 WP_158046931.1 hypothetical protein -
DPR14_RS21290 4625623..4626441 - 819 WP_158046932.1 hypothetical protein -
DPR14_RS21295 4626638..4626928 - 291 WP_211104064.1 HigA family addiction module antidote protein Antitoxin
DPR14_RS21300 4627019..4627300 - 282 WP_158046934.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DPR14_RS21305 4627418..4628029 - 612 WP_158046935.1 hypothetical protein -
DPR14_RS21310 4628075..4629526 - 1452 WP_158046936.1 head-tail connector protein -
DPR14_RS21315 4629531..4629935 - 405 WP_158046937.1 hypothetical protein -
DPR14_RS21320 4629960..4630409 - 450 WP_158046938.1 hypothetical protein -
DPR14_RS21325 4630406..4630738 - 333 Protein_4248 hypothetical protein -
DPR14_RS21330 4631003..4631635 + 633 WP_158046939.1 helix-turn-helix transcriptional regulator -
DPR14_RS21335 4631708..4632043 + 336 WP_158046940.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4615726..4633654 17928


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-85)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10541.14 Da        Isoelectric Point: 8.0374

>T107424 WP_158046934.1 NZ_CP030265:c4627300-4627019 [Skermanella pratensis]
VIKTFADKGTAALFQGHFLKGMPADIQRRALVKLVLIDTAVTVEDLRVPPGNRLEALRGDRQGQYSIRVNGQWRICFVWK
DGDAFEVEIVDYH

Download         Length: 282 bp

>T107424 NZ_CP030265:c4627300-4627019 [Skermanella pratensis]
GTGATCAAGACCTTCGCAGACAAAGGCACCGCCGCCCTGTTCCAAGGCCACTTCCTGAAAGGGATGCCGGCCGACATCCA
GCGCCGTGCGCTGGTGAAGCTCGTATTGATCGATACCGCCGTGACCGTGGAGGACCTGCGTGTCCCTCCCGGCAATCGCC
TGGAAGCCTTGCGCGGAGACCGCCAAGGCCAATACAGCATCAGGGTCAACGGCCAGTGGCGCATCTGCTTCGTCTGGAAG
GATGGCGATGCTTTCGAGGTGGAGATCGTCGACTACCATTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10534.30 Da        Isoelectric Point: 9.0063

>AT107424 WP_211104064.1 NZ_CP030265:c4626928-4626638 [Skermanella pratensis]
MLLPVHPGEILSEEFLGPLCISAYKLAKDVGVPATRIHAIVTGKRGITGDTALRLGRYFGTSAQMWINLQARYDLEIARR
EVGDRVVAEVVPFRAA

Download         Length: 291 bp

>AT107424 NZ_CP030265:c4626928-4626638 [Skermanella pratensis]
ATGCTGCTGCCCGTTCACCCCGGTGAGATCCTGTCGGAGGAGTTTCTCGGCCCGCTTTGCATTTCGGCTTACAAACTGGC
GAAAGACGTGGGTGTGCCGGCAACGCGCATTCACGCCATCGTCACCGGAAAGCGCGGCATCACCGGGGATACCGCGCTCA
GGCTCGGCCGGTATTTCGGCACCTCCGCGCAGATGTGGATCAATCTCCAGGCCCGGTATGATTTGGAAATAGCCCGCCGG
GAAGTCGGCGACAGGGTCGTGGCCGAGGTCGTGCCGTTCCGGGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References