Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4101947..4102544 Replicon chromosome
Accession NZ_CP030173
Organism Klebsiella variicola strain 13450

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DQB70_RS20590 Protein ID WP_012968756.1
Coordinates 4102227..4102544 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DQB70_RS20585 Protein ID WP_012542525.1
Coordinates 4101947..4102234 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQB70_RS20555 4097977..4098225 + 249 WP_022064667.1 DUF1158 domain-containing protein -
DQB70_RS20560 4098242..4098583 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
DQB70_RS20565 4098614..4099729 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
DQB70_RS20570 4099909..4100490 + 582 WP_046881940.1 TetR/AcrR family transcriptional regulator -
DQB70_RS20575 4100490..4100858 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
DQB70_RS20580 4100978..4101631 + 654 WP_039102940.1 oxygen-insensitive NAD(P)H nitroreductase -
DQB70_RS20585 4101947..4102234 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
DQB70_RS20590 4102227..4102544 - 318 WP_012968756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQB70_RS20595 4102729..4103772 - 1044 WP_016160437.1 DUF2157 domain-containing protein -
DQB70_RS20605 4104299..4105165 - 867 WP_022065427.1 helix-turn-helix transcriptional regulator -
DQB70_RS20610 4105274..4106701 + 1428 WP_022065426.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12124.41 Da        Isoelectric Point: 11.2767

>T107307 WP_012968756.1 NZ_CP030173:c4102544-4102227 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
IKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T107307 NZ_CP030173:c4102544-4102227 [Klebsiella variicola]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
ATCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT107307 WP_012542525.1 NZ_CP030173:c4102234-4101947 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp

>AT107307 NZ_CP030173:c4102234-4101947 [Klebsiella variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References