Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1843647..1844149 Replicon chromosome
Accession NZ_CP030152
Organism Escherichia coli strain JSMCR1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8E0FJZ4
Locus tag JSMCR1_RS08700 Protein ID WP_000767833.1
Coordinates 1843895..1844149 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JSMCR1_RS08695 Protein ID WP_001259255.1
Coordinates 1843647..1843898 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSMCR1_RS08670 (1838824) 1838824..1839891 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JSMCR1_RS08675 (1839891) 1839891..1840961 - 1071 WP_256625336.1 histidinol-phosphate transaminase -
JSMCR1_RS08680 (1840964) 1840964..1842262 - 1299 WP_219388200.1 histidinol dehydrogenase -
JSMCR1_RS08685 (1842268) 1842268..1843167 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JSMCR1_RS08690 (1843313) 1843313..1843363 - 51 WP_001364200.1 his operon leader peptide -
JSMCR1_RS08695 (1843647) 1843647..1843898 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JSMCR1_RS08700 (1843895) 1843895..1844149 + 255 WP_000767833.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JSMCR1_RS08705 (1844232) 1844232..1845056 + 825 WP_256625337.1 SDR family oxidoreductase -
JSMCR1_RS08710 (1845102) 1845102..1846031 + 930 WP_130060054.1 LysR substrate-binding domain-containing protein -
JSMCR1_RS08715 (1846246) 1846246..1846308 + 63 WP_010723108.1 membrane protein YoeI -
JSMCR1_RS08720 (1846298) 1846298..1847656 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JSMCR1_RS08725 (1847835) 1847835..1848893 + 1059 WP_097413635.1 thiosulfate utilization transporter TsuA/YeeE -
JSMCR1_RS08730 (1848907) 1848907..1849134 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10173.54 Da        Isoelectric Point: 8.0353

>T107226 WP_000767833.1 NZ_CP030152:1843895-1844149 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPESLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T107226 NZ_CP030152:1843895-1844149 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAATCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT107226 WP_001259255.1 NZ_CP030152:1843647-1843898 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT107226 NZ_CP030152:1843647-1843898 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References