Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 734802..735495 Replicon chromosome
Accession NZ_CP030152
Organism Escherichia coli strain JSMCR1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JSMCR1_RS03575 Protein ID WP_000415584.1
Coordinates 734802..735098 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JSMCR1_RS03580 Protein ID WP_000650107.1
Coordinates 735100..735495 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSMCR1_RS03540 (729890) 729890..730204 - 315 WP_000958598.1 putative quinol monooxygenase -
JSMCR1_RS03545 (730235) 730235..730816 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JSMCR1_RS03550 (731135) 731135..731467 + 333 WP_000917684.1 DUF2645 family protein -
JSMCR1_RS03555 (731513) 731513..732862 - 1350 WP_000673409.1 quorum sensing histidine kinase QseC -
JSMCR1_RS03560 (732859) 732859..733518 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
JSMCR1_RS03565 (733670) 733670..734062 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JSMCR1_RS03570 (734115) 734115..734597 + 483 WP_000183505.1 GyrI-like domain-containing protein -
JSMCR1_RS03575 (734802) 734802..735098 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JSMCR1_RS03580 (735100) 735100..735495 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JSMCR1_RS03585 (735628) 735628..737235 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JSMCR1_RS03590 (737373) 737373..739631 + 2259 WP_181203556.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T107223 WP_000415584.1 NZ_CP030152:734802-735098 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T107223 NZ_CP030152:734802-735098 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT107223 WP_000650107.1 NZ_CP030152:735100-735495 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT107223 NZ_CP030152:735100-735495 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References