107214

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2690470..2690987 Replicon chromosome
Accession NZ_CP030138
Organism Staphylococcus aureus strain M48

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag C2G36_RS14425 Protein ID WP_000113262.1
Coordinates 2690470..2690736 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag C2G36_RS14430 Protein ID WP_000584499.1
Coordinates 2690736..2690987 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2G36_RS14395 2685896..2686432 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
C2G36_RS14400 2686665..2687489 - 825 WP_000572040.1 formate/nitrite transporter family protein -
C2G36_RS14405 2687706..2687888 - 183 WP_000230294.1 hypothetical protein -
C2G36_RS14410 2687972..2688439 - 468 WP_000153344.1 SRPBCC domain-containing protein -
C2G36_RS14415 2688625..2690175 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
C2G36_RS14420 2690364..2690435 - 72 Protein_2679 hypothetical protein -
C2G36_RS14425 2690470..2690736 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
C2G36_RS14430 2690736..2690987 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C2G36_RS14435 2691152..2691253 - 102 WP_001791744.1 hypothetical protein -
C2G36_RS14440 2691260..2691859 - 600 WP_000162813.1 DsbA family protein -
C2G36_RS14445 2691878..2692240 - 363 WP_000819843.1 DUF4467 domain-containing protein -
C2G36_RS14450 2692495..2693745 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
C2G36_RS14455 2693842..2694573 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
C2G36_RS14460 2694570..2695289 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T107214 WP_000113262.1 NZ_CP030138:c2690736-2690470 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T107214 NZ_CP030138:c2690736-2690470 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT107214 WP_000584499.1 NZ_CP030138:c2690987-2690736 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT107214 NZ_CP030138:c2690987-2690736 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References