Detailed information of TA system TA107203

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2119851..2120150
• Replicon: chromosome
• Accession: NZ_CP030138
• Organism: Staphylococcus aureus strain M48

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: C2G36_RS11190
• Protein ID: WP_072482930.1
• Coordinates: 2119974..2120150 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2119851..2119906 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2G36_RS11135	2115409..2115588	+	180	WP_000669789.1	hypothetical protein	-
C2G36_RS11145	2115899..2116159	+	261	WP_001791826.1	hypothetical protein	-
C2G36_RS11150	2116212..2116562	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
C2G36_RS11155	2117072..2117407	-	336	Protein_2057	SH3 domain-containing protein	-
C2G36_RS11170	2118059..2118550	-	492	WP_000920041.1	staphylokinase	-
C2G36_RS11175	2118741..2119496	-	756	WP_000861038.1	CHAP domain-containing protein	-
C2G36_RS11180	2119508..2119762	-	255	WP_000611512.1	phage holin	-
C2G36_RS11185	2119814..2119921	+	108	Protein_2061	hypothetical protein	-
-	2119843..2119982	+	140	NuclAT_0	-	-
-	2119843..2119982	+	140	NuclAT_0	-	-
-	2119843..2119982	+	140	NuclAT_0	-	-
-	2119843..2119982	+	140	NuclAT_0	-	-
-	2119851..2119906	+	56	-	-	Antitoxin
C2G36_RS11190	2119974..2120150	-	177	WP_072482930.1	putative holin-like toxin	Toxin
C2G36_RS11195	2120259..2121032	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
C2G36_RS11200	2121405..2121779	-	375	WP_000340977.1	hypothetical protein	-
C2G36_RS11205	2121835..2122122	-	288	WP_001262621.1	hypothetical protein	-
C2G36_RS11210	2122168..2122320	-	153	WP_001000059.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2116212..2175057	58845

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T107203 WP_072482930.1 NZ_CP030138:c2120150-2119974 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T107203 NZ_CP030138:c2120150-2119974 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT107203 NZ_CP030138:2119851-2119906 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin