Detailed information of TA system TA107190

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 761589..761927
• Replicon: chromosome
• Accession: NZ_CP030137
• Organism: Staphylococcus aureus strain M51

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: C2G35_RS04125
• Protein ID: WP_011447039.1
• Coordinates: 761589..761765 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	761753..761927 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2G35_RS04105	756824..760609	+	3786	WP_129364302.1	hypothetical protein	-
C2G35_RS04110	760599..760751	+	153	WP_001153681.1	hypothetical protein	-
C2G35_RS04115	760798..761085	+	288	WP_001040261.1	hypothetical protein	-
C2G35_RS04120	761143..761439	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
C2G35_RS04125	761589..761765	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	761753..761927	-	175	-	-	Antitoxin
C2G35_RS04135	761977..762231	+	255	WP_000611512.1	phage holin	-
C2G35_RS04140	762243..762998	+	756	WP_000861038.1	CHAP domain-containing protein	-
C2G35_RS04145	763189..763680	+	492	WP_000919350.1	staphylokinase	-
C2G35_RS04165	764331..764666	+	336	Protein_777	SH3 domain-containing protein	-
C2G35_RS04170	765177..765527	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
C2G35_RS04175	765580..765840	-	261	WP_001791826.1	hypothetical protein	-
C2G35_RS04185	766151..766330	-	180	WP_000669791.1	hypothetical protein	-
C2G35_RS04190	766652..766902	-	251	Protein_781	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / scn	706393..765527	59134

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T107190 WP_011447039.1 NZ_CP030137:761589-761765 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T107190 NZ_CP030137:761589-761765 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT107190 NZ_CP030137:c761927-761753 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin