Detailed information of TA system TA107185

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 586095..586374
• Replicon: chromosome
• Accession: NZ_CP030137
• Organism: Staphylococcus aureus strain M51

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: C2G35_RS03095
• Protein ID: WP_001802298.1
• Coordinates: 586095..586199 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	586195..586374 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2G35_RS03070	581480..582262	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
C2G35_RS03075	582330..583187	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
C2G35_RS03080	583892..583984	-	93	WP_001790138.1	hypothetical protein	-
C2G35_RS03085	584272..585408	+	1137	WP_000115564.1	SAP domain-containing protein	-
C2G35_RS14665	585451..585934	+	484	Protein_578	recombinase family protein	-
C2G35_RS03095	586095..586199	+	105	WP_001802298.1	hypothetical protein	Toxin
-	586195..586374	-	180	-	-	Antitoxin
C2G35_RS03100	586699..587790	-	1092	WP_000495671.1	lytic regulatory protein	-
C2G35_RS03105	588056..589036	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
C2G35_RS03110	589038..589358	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
C2G35_RS03115	589510..590175	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T107185 WP_001802298.1 NZ_CP030137:586095-586199 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T107185 NZ_CP030137:586095-586199 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT107185 NZ_CP030137:c586374-586195 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin