Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 825426..825840 Replicon chromosome
Accession NZ_CP030136
Organism Staphylococcus aureus strain S57

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CHN55_RS04485 Protein ID WP_031886311.1
Coordinates 825426..825677 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CHN55_RS14885 Protein ID WP_000028424.1
Coordinates 825667..825840 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHN55_RS04415 821002..821160 + 159 WP_000628839.1 hypothetical protein -
CHN55_RS04420 821173..821394 + 222 WP_001123692.1 DUF3269 family protein -
CHN55_RS04425 821405..821809 + 405 WP_000049789.1 DUF1064 domain-containing protein -
CHN55_RS04430 821814..821999 + 186 WP_129409665.1 DUF3113 family protein -
CHN55_RS04435 822000..822617 + 618 WP_000907339.1 hypothetical protein -
CHN55_RS04440 822617..822871 + 255 WP_000022719.1 DUF3310 domain-containing protein -
CHN55_RS04445 822871..823119 + 249 WP_060474161.1 hypothetical protein -
CHN55_RS04450 823133..823339 + 207 WP_000693989.1 hypothetical protein -
CHN55_RS04455 823342..823746 + 405 WP_031886354.1 hypothetical protein -
CHN55_RS04460 823743..823937 + 195 WP_000983953.1 hypothetical protein -
CHN55_RS04465 823934..824386 + 453 WP_000982706.1 hypothetical protein -
CHN55_RS04470 824383..824706 + 324 Protein_827 hypothetical protein -
CHN55_RS04475 824781..825128 + 348 WP_000979209.1 hypothetical protein -
CHN55_RS04480 825125..825433 + 309 WP_060585319.1 hypothetical protein -
CHN55_RS04485 825426..825677 + 252 WP_031886311.1 DUF1024 family protein Toxin
CHN55_RS14885 825667..825840 + 174 WP_000028424.1 hypothetical protein Antitoxin
CHN55_RS14890 825841..826002 + 162 WP_000889680.1 hypothetical protein -
CHN55_RS04490 826017..826523 + 507 WP_001061834.1 dUTPase -
CHN55_RS04495 826560..826766 + 207 WP_129409666.1 DUF1381 domain-containing protein -
CHN55_RS04500 826763..827149 + 387 WP_000592215.1 hypothetical protein -
CHN55_RS04505 827146..827298 + 153 WP_045179128.1 transcriptional activator RinB -
CHN55_RS04510 827366..827566 + 201 WP_031886313.1 DUF1514 family protein -
CHN55_RS04515 827618..830065 + 2448 WP_129409667.1 virulence-associated E family protein -
CHN55_RS04525 830167..830271 - 105 WP_078098968.1 hypothetical protein -
CHN55_RS04530 830405..830695 + 291 WP_000665205.1 VRR-NUC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 811892..858679 46787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.28 Da        Isoelectric Point: 3.8567

>T107175 WP_031886311.1 NZ_CP030136:825426-825677 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T107175 NZ_CP030136:825426-825677 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATACAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT107175 WP_000028424.1 NZ_CP030136:825667-825840 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT107175 NZ_CP030136:825667-825840 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References