Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 331665..332182 Replicon chromosome
Accession NZ_CP030136
Organism Staphylococcus aureus strain S57

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag CHN55_RS01735 Protein ID WP_000113262.1
Coordinates 331916..332182 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CHN55_RS01730 Protein ID WP_000584499.1
Coordinates 331665..331916 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHN55_RS01700 327363..328082 + 720 WP_000479576.1 amino acid ABC transporter permease -
CHN55_RS01705 328079..328810 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CHN55_RS01710 328907..330157 - 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
CHN55_RS01715 330412..330774 + 363 WP_000819843.1 DUF4467 domain-containing protein -
CHN55_RS01720 330793..331392 + 600 WP_000162813.1 DsbA family protein -
CHN55_RS01725 331399..331500 + 102 WP_031774922.1 hypothetical protein -
CHN55_RS01730 331665..331916 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CHN55_RS01735 331916..332182 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
CHN55_RS01740 332478..334028 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CHN55_RS01745 334214..334681 + 468 WP_000153344.1 SRPBCC domain-containing protein -
CHN55_RS01750 334765..334947 + 183 WP_000230294.1 hypothetical protein -
CHN55_RS01755 335164..335988 + 825 WP_000572040.1 formate/nitrite transporter family protein -
CHN55_RS01760 336221..336757 + 537 WP_031585827.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T107167 WP_000113262.1 NZ_CP030136:331916-332182 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T107167 NZ_CP030136:331916-332182 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT107167 WP_000584499.1 NZ_CP030136:331665-331916 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT107167 NZ_CP030136:331665-331916 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References