Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 78036..78693 | Replicon | plasmid pIncAC2_L111 |
| Accession | NZ_CP030132 | ||
| Organism | Klebsiella pneumoniae strain 160111 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | DL890_RS28215 | Protein ID | WP_000270043.1 |
| Coordinates | 78036..78386 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | DL890_RS28220 | Protein ID | WP_000124640.1 |
| Coordinates | 78391..78693 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DL890_RS28175 | 74510..75007 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| DL890_RS28180 | 75010..75498 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| DL890_RS28185 | 75595..75930 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| DL890_RS28190 | 75945..76415 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| DL890_RS28195 | 76408..76779 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| DL890_RS28200 | 76790..76984 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| DL890_RS28210 | 77325..77873 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| DL890_RS28215 | 78036..78386 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| DL890_RS28220 | 78391..78693 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| DL890_RS28225 | 78720..79013 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| DL890_RS28230 | 79101..79373 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| DL890_RS28235 | 79431..79958 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| DL890_RS28245 | 80189..81046 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| DL890_RS28250 | 81033..81263 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| DL890_RS28255 | 81263..81781 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| DL890_RS28260 | 81778..82224 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| DL890_RS28265 | 82224..82583 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| DL890_RS28270 | 82640..83068 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / aac(3)-IId / dfrA12 / aadA2 / qacE / floR / tet(G) / rmtB / blaTEM-2 / erm(42) / blaCTX-M-14 / catB3 / blaOXA-10 / aph(3')-Ia / dfrA14 / ARR-3 / cmlA1 / ant(3'')-Ia / sul1 / blaDHA-1 / blaCMY-2 | - | 1..194181 | 194181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T107158 WP_000270043.1 NZ_CP030132:78036-78386 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T107158 NZ_CP030132:78036-78386 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT107158 WP_000124640.1 NZ_CP030132:78391-78693 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT107158 NZ_CP030132:78391-78693 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|