Detailed information of TA system TA107153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3144495..3145185
• Replicon: chromosome
• Accession: NZ_CP030126
• Organism: Indioceanicola profundi strain SCSIO 08040

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DOL89_RS15050
• Protein ID: WP_119679882.1
• Coordinates: 3144799..3145185 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DOL89_RS15045
• Protein ID: WP_119679881.1
• Coordinates: 3144495..3144815 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOL89_RS15030	3140889..3141965	+	1077	WP_162937544.1	MBL fold metallo-hydrolase	-
DOL89_RS15035	3142019..3143944	+	1926	WP_205574598.1	AMP-binding protein	-
DOL89_RS15040	3144093..3144488	+	396	WP_162937545.1	nuclear transport factor 2 family protein	-
DOL89_RS15045	3144495..3144815	-	321	WP_119679881.1	XRE family transcriptional regulator	Antitoxin
DOL89_RS15050	3144799..3145185	-	387	WP_119679882.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DOL89_RS15055	3145353..3147392	+	2040	WP_119679883.1	cobaltochelatase subunit CobT	-
DOL89_RS15060	3147455..3148477	-	1023	WP_119679884.1	fumarylacetoacetate hydrolase family protein	-
DOL89_RS15065	3148606..3149742	-	1137	WP_119679885.1	homogentisate 1,2-dioxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3114560..3321573	207013

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14406.64 Da
• Isoelectric Point: 10.3331

>T107153 WP_119679882.1 NZ_CP030126:c3145185-3144799 [Indioceanicola profundi]
MAWLVRFHDEFELEFLALTAAVQDELLAHAKLLAAEGPALGRPHVDTLAGSKHANMKEMRFMAANGVWRVAFAFDPERAA
ILLVAGDKAGVSQKRFYRGLVERADRRFDDHLQSLKAKRKDRKHGPIT

Nucleotide

• Length: 387 bp

>T107153 NZ_CP030126:c3145185-3144799 [Indioceanicola profundi]
ATGGCTTGGCTGGTCCGCTTCCATGATGAATTCGAGCTGGAGTTCCTGGCGCTGACCGCTGCCGTCCAGGATGAATTGCT
TGCGCATGCGAAGCTGCTGGCTGCCGAGGGACCGGCATTGGGGCGTCCGCACGTTGATACCCTAGCCGGATCGAAGCACG
CCAACATGAAGGAAATGCGCTTCATGGCGGCCAACGGCGTCTGGCGCGTGGCATTCGCCTTCGATCCGGAGCGGGCTGCC
ATCCTGCTGGTGGCGGGAGACAAGGCCGGCGTCTCGCAGAAGCGGTTCTATCGTGGCTTGGTGGAGCGGGCCGACCGCCG
CTTCGATGATCACCTGCAAAGCCTGAAGGCAAAGCGGAAGGACAGGAAACATGGGCCGATCACTTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11658.43 Da
• Isoelectric Point: 7.0196

>AT107153 WP_119679881.1 NZ_CP030126:c3144815-3144495 [Indioceanicola profundi]
MGRSLDEVMSSLPPERREAIEARAAALTAEVEGLRALRVLAERSQEQIADALGIKQPSVHKMERQADLYLSTLRRFVEAA
GGTLELRVQLPGKEPIRLSGIGDIRP

Nucleotide

• Length: 321 bp

>AT107153 NZ_CP030126:c3144815-3144495 [Indioceanicola profundi]
ATGGGCCGATCACTTGACGAGGTCATGAGCAGCCTGCCGCCGGAGCGGCGCGAGGCCATAGAGGCGCGGGCTGCGGCGTT
GACTGCGGAGGTCGAGGGGCTGCGCGCATTGCGGGTCCTTGCCGAGCGCAGCCAGGAGCAGATCGCCGATGCCCTTGGCA
TCAAACAGCCGTCGGTCCACAAGATGGAGCGGCAGGCGGACCTGTACCTGTCCACGCTACGGCGTTTCGTGGAGGCGGCG
GGCGGAACATTGGAGCTGCGCGTGCAGCTTCCCGGCAAGGAACCGATCCGGCTTTCGGGGATCGGCGATATCCGCCCCTG
A