Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 120258..120844 Replicon chromosome
Accession NZ_CP030126
Organism Indioceanicola profundi strain SCSIO 08040

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DOL89_RS00565 Protein ID WP_119677399.1
Coordinates 120258..120539 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DOL89_RS00570 Protein ID WP_119677400.1
Coordinates 120551..120844 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOL89_RS00545 116028..116810 - 783 WP_119677395.1 hypothetical protein -
DOL89_RS00550 116858..117739 + 882 WP_119677396.1 SDR family oxidoreductase -
DOL89_RS00555 117809..118621 + 813 WP_119677397.1 bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE -
DOL89_RS00560 118632..120179 + 1548 WP_119677398.1 2-polyprenylphenol 6-hydroxylase -
DOL89_RS00565 120258..120539 + 282 WP_119677399.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DOL89_RS00570 120551..120844 + 294 WP_119677400.1 HigA family addiction module antidote protein Antitoxin
DOL89_RS00575 121060..121362 + 303 WP_162937252.1 hypothetical protein -
DOL89_RS00580 121490..121960 + 471 WP_119680144.1 MmcB family DNA repair protein -
DOL89_RS00585 121961..123265 - 1305 WP_119680145.1 hypothetical protein -
DOL89_RS00590 123351..123947 - 597 WP_119677402.1 BON domain-containing protein -
DOL89_RS00595 124075..124887 - 813 WP_119677403.1 N-acetylmuramoyl-L-alanine amidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(19-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-92)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10487.05 Da        Isoelectric Point: 11.1025

>T107146 WP_119677399.1 NZ_CP030126:120258-120539 [Indioceanicola profundi]
MIGGFKGRLAEAVWRGRNGKGFPADLIRPAQRKLAMLAAAVDLNALRQPPGNRLEALKGSRQGQHSIRINDQWRICFVWR
DNAAHDVEIVDYH

Download         Length: 282 bp

>T107146 NZ_CP030126:120258-120539 [Indioceanicola profundi]
ATGATCGGAGGCTTCAAGGGCCGGTTGGCTGAAGCCGTCTGGCGCGGCAGAAACGGCAAGGGCTTTCCAGCCGACCTGAT
CCGCCCGGCGCAACGGAAACTGGCGATGCTTGCCGCTGCGGTCGATCTGAATGCTCTTCGGCAGCCGCCGGGCAACCGGC
TGGAAGCATTGAAGGGAAGCCGCCAGGGCCAGCATTCAATCCGCATCAATGATCAGTGGCGGATATGTTTCGTCTGGCGG
GATAACGCTGCCCATGACGTCGAAATCGTCGATTATCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10796.55 Da        Isoelectric Point: 6.4508

>AT107146 WP_119677400.1 NZ_CP030126:120551-120844 [Indioceanicola profundi]
MIGPYPPVHPGEILQEEFLGPMGLTPYAVAKACRVPRTRIERLARCETPVTADTALRLGRVFNTGPEFWMNLQTLHDLAT
TELNAKDIRDIQPLIAA

Download         Length: 294 bp

>AT107146 NZ_CP030126:120551-120844 [Indioceanicola profundi]
ATGATCGGCCCATATCCTCCCGTGCATCCGGGCGAAATCCTTCAGGAGGAGTTTCTCGGACCCATGGGGCTCACGCCCTA
TGCCGTTGCCAAGGCCTGCCGCGTGCCGCGCACCCGGATAGAACGGCTGGCCCGGTGCGAAACGCCGGTTACGGCTGATA
CGGCTCTCCGGCTTGGTCGGGTGTTCAATACGGGGCCGGAGTTCTGGATGAATCTTCAGACCCTGCACGACCTTGCGACG
ACGGAGCTGAACGCCAAGGATATCCGGGATATCCAGCCCTTGATCGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References