Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2048380..2048899 Replicon chromosome
Accession NZ_CP030124
Organism Streptococcus suis strain SH1510

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag DP111_RS10330 Protein ID WP_013730620.1
Coordinates 2048380..2048637 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag DP111_RS10335 Protein ID WP_002939010.1
Coordinates 2048639..2048899 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP111_RS10315 2044851..2046581 - 1731 WP_009910905.1 membrane protein -
DP111_RS10320 2046944..2047852 - 909 WP_074411269.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
DP111_RS10325 2047836..2048366 - 531 WP_009910909.1 DUF1697 domain-containing protein -
DP111_RS10330 2048380..2048637 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
DP111_RS10335 2048639..2048899 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DP111_RS10340 2048975..2049430 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
DP111_RS10345 2049434..2049802 - 369 WP_013730622.1 hypothetical protein -
DP111_RS10350 2049795..2050364 - 570 WP_022540720.1 ribonuclease M5 -
DP111_RS10355 2050348..2051130 - 783 WP_002939015.1 TatD family hydrolase -
DP111_RS10360 2051238..2051375 - 138 WP_002939016.1 50S ribosomal protein L34 -
DP111_RS10365 2051543..2052538 - 996 WP_012775367.1 protein jag -
DP111_RS10370 2052558..2053370 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
DP111_RS10375 2053354..2053713 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T107142 WP_013730620.1 NZ_CP030124:c2048637-2048380 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T107142 NZ_CP030124:c2048637-2048380 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT107142 WP_002939010.1 NZ_CP030124:c2048899-2048639 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT107142 NZ_CP030124:c2048899-2048639 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References