Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4031419..4031677 Replicon chromosome
Accession NZ_CP030111
Organism Escherichia coli strain MCJCHV-1

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag DPQ29_RS20800 Protein ID WP_000809168.1
Coordinates 4031525..4031677 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4031419..4031476 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPQ29_RS20780 4027248..4028507 - 1260 WP_000494929.1 hypothetical protein -
DPQ29_RS20785 4028636..4030129 - 1494 WP_001774152.1 sulfatase-like hydrolase/transferase -
DPQ29_RS20790 4030149..4030910 - 762 WP_001274832.1 hypothetical protein -
- 4031419..4031476 - 58 - - Antitoxin
DPQ29_RS20800 4031525..4031677 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
DPQ29_RS20805 4031782..4032912 - 1131 WP_001118464.1 molecular chaperone DnaJ -
DPQ29_RS20810 4033001..4034917 - 1917 WP_000516135.1 molecular chaperone DnaK -
DPQ29_RS20815 4035289..4035693 + 405 WP_000843687.1 DUF2541 family protein -
DPQ29_RS20820 4035719..4036432 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T107126 WP_000809168.1 NZ_CP030111:4031525-4031677 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T107126 NZ_CP030111:4031525-4031677 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT107126 NZ_CP030111:c4031476-4031419 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References