Detailed information of TA system TA107105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 66197..66855
• Replicon: plasmid pDA33382-85
• Accession: NZ_CP030109
• Organism: Acinetobacter baumannii strain DA33382

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DPV67_RS19690
• Protein ID: WP_000312250.1
• Coordinates: 66496..66855 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DPV67_RS19685
• Protein ID: WP_001096429.1
• Coordinates: 66197..66496 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DPV67_RS19640	61221..62501	+	1281	WP_001093570.1	hypothetical protein	-
DPV67_RS19645	62606..62863	+	258	WP_000834290.1	hypothetical protein	-
DPV67_RS19650	62868..63440	+	573	WP_000443897.1	hypothetical protein	-
DPV67_RS19655	63416..63595	+	180	WP_000387630.1	hypothetical protein	-
DPV67_RS19660	63612..64241	+	630	WP_000701003.1	hypothetical protein	-
DPV67_RS19665	64281..64499	+	219	WP_001043201.1	hypothetical protein	-
DPV67_RS19670	64519..65073	+	555	WP_000790084.1	hypothetical protein	-
DPV67_RS19675	65123..65659	+	537	WP_000731978.1	hypothetical protein	-
DPV67_RS19685	66197..66496	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
DPV67_RS19690	66496..66855	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DPV67_RS19695	67056..67622	+	567	WP_000710385.1	hypothetical protein	-
DPV67_RS19700	67671..67853	+	183	WP_000373385.1	hypothetical protein	-
DPV67_RS19705	67920..68228	+	309	Protein_86	hypothetical protein	-
DPV67_RS19710	68288..69313	+	1026	WP_001988464.1	IS30-like element ISAba125 family transposase	-
DPV67_RS19715	69324..69530	+	207	Protein_88	RepB family plasmid replication initiator protein	-
DPV67_RS19720	69595..70299	+	705	WP_001067856.1	IS6-like element IS26 family transposase	-
DPV67_RS19725	70410..70742	-	333	Protein_90	IS1 family transposase	-
DPV67_RS19730	70739..71701	-	963	WP_004746678.1	IS30 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aph(3')-VIa / blaOXA-164	-	1..84678	84678

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T107105 WP_000312250.1 NZ_CP030109:c66855-66496 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T107105 NZ_CP030109:c66855-66496 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT107105 WP_001096429.1 NZ_CP030109:c66496-66197 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT107105 NZ_CP030109:c66496-66197 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA