Detailed information of TA system TA107101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 112583..113100
• Replicon: chromosome
• Accession: NZ_CP030099
• Organism: Roseovarius sp. AK1035

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A5E7XUB5
• Locus tag: RAK1035_RS00600
• Protein ID: WP_008280672.1
• Coordinates: 112831..113100 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: RAK1035_RS00595
• Protein ID: WP_008280671.1
• Coordinates: 112583..112834 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RAK1035_RS00580	108610..109500	-	891	WP_008280668.1	LysR family transcriptional regulator	-
RAK1035_RS00585	109602..110918	+	1317	WP_037297475.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
RAK1035_RS00590	111051..112331	-	1281	WP_008280670.1	DUF3422 domain-containing protein	-
RAK1035_RS00595	112583..112834	+	252	WP_008280671.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
RAK1035_RS00600	112831..113100	+	270	WP_008280672.1	Txe/YoeB family addiction module toxin	Toxin
RAK1035_RS00605	113154..114587	-	1434	WP_008280673.1	NAD(P)(+) transhydrogenase (Re/Si-specific) subunit beta	-
RAK1035_RS00610	114601..116175	-	1575	WP_008280674.1	Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha	-
RAK1035_RS00615	116303..116737	-	435	WP_008280675.1	isoprenylcysteine carboxylmethyltransferase family protein	-
RAK1035_RS00620	116832..117584	+	753	WP_037297558.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10534.94 Da
• Isoelectric Point: 9.9477

>T107101 WP_008280672.1 NZ_CP030099:112831-113100 [Roseovarius sp. AK1035]
VRLVFSDDAWEDFLWWQSTGRDKGLNRVIDLINATKRLPFKGIGKPEPLKGDLTGWWSRRITDEHRFVYRVSGKGESQQL
DIAQLRYHY

Nucleotide

• Length: 270 bp

>T107101 NZ_CP030099:112831-113100 [Roseovarius sp. AK1035]
GTGAGGTTGGTCTTTTCCGACGACGCTTGGGAAGATTTTCTCTGGTGGCAATCCACCGGGCGCGACAAGGGGCTGAACCG
GGTCATTGATCTGATCAACGCCACCAAGCGCCTGCCGTTCAAGGGCATCGGCAAGCCTGAACCGCTCAAAGGCGATCTCA
CCGGCTGGTGGTCACGCCGGATCACCGACGAACATCGCTTTGTCTACCGCGTGAGCGGCAAGGGCGAGAGCCAACAGCTC
GACATTGCGCAGCTCAGATATCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9436.71 Da
• Isoelectric Point: 6.2215

>AT107101 WP_008280671.1 NZ_CP030099:112583-112834 [Roseovarius sp. AK1035]
MDVFTYTDARASLKEVMDRVIHDRTEVVVTRKNREAVVMISLDEYNAIQETLHLLKSPENARRLHRSIAQLTAGDGIARD
IDG

Nucleotide

• Length: 252 bp

>AT107101 NZ_CP030099:112583-112834 [Roseovarius sp. AK1035]
ATGGACGTGTTCACCTATACCGATGCCCGCGCCTCGCTCAAAGAGGTGATGGACCGCGTCATTCACGACCGCACAGAGGT
GGTCGTCACCCGCAAGAACCGCGAGGCGGTGGTGATGATCTCGCTCGACGAATACAACGCCATTCAGGAAACCCTCCACC
TCCTCAAAAGCCCGGAAAACGCCCGCCGTCTGCACCGCTCGATTGCGCAACTGACCGCCGGGGATGGCATAGCGCGTGAC
ATCGACGGGTGA

Structures

Toxin

• AlphaFold DB: A0A5E7XUB5