Detailed information of TA system TA106937

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2714166..2714440
• Replicon: chromosome
• Accession: NZ_CP030045
• Organism: Enterococcus faecalis strain C54

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: DOU32_RS13860
• Protein ID: WP_073340360.1
• Coordinates: 2714166..2714306 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2714239..2714440 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOU32_RS13835	2709373..2710365	+	993	WP_002358973.1	biotin--[acetyl-CoA-carboxylase] ligase	-
DOU32_RS13840	2710629..2711267	-	639	WP_073438309.1	lytic polysaccharide monooxygenase	-
DOU32_RS13850	2711953..2713569	+	1617	WP_002406969.1	phosphatase PAP2/LCP family protein	-
DOU32_RS13855	2713898..2714047	+	150	WP_002411240.1	putative holin-like toxin	-
-	2713980..2714164	-	185	NuclAT_9	-	-
-	2714021..2714164	-	144	NuclAT_11	-	-
DOU32_RS13860	2714166..2714306	+	141	WP_073340360.1	putative holin-like toxin	Toxin
-	2714239..2714440	-	202	NuclAT_7	-	Antitoxin
DOU32_RS13865	2714537..2714680	+	144	WP_073437820.1	putative holin-like toxin	-
-	2714612..2714874	-	263	NuclAT_10	-	-
-	2714824..2714873	+	50	NuclAT_13	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T106937 WP_073340360.1 NZ_CP030045:2714166-2714306 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T106937 NZ_CP030045:2714166-2714306 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 202 bp

>AT106937 NZ_CP030045:c2714440-2714239 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin