Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2713980..2714306 Replicon chromosome
Accession NZ_CP030045
Organism Enterococcus faecalis strain C54

Toxin (Protein)


Gene name txpA Uniprot ID A0A3N3Z2N6
Locus tag DOU32_RS13860 Protein ID WP_073340360.1
Coordinates 2714166..2714306 (+) Length 47 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2713980..2714164 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOU32_RS13830 2709019..2709234 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
DOU32_RS13835 2709373..2710365 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
DOU32_RS13840 2710629..2711267 - 639 WP_073438309.1 lytic polysaccharide monooxygenase -
DOU32_RS13850 2711953..2713569 + 1617 WP_002406969.1 phosphatase PAP2/LCP family protein -
DOU32_RS13855 2713898..2714047 + 150 WP_002411240.1 putative holin-like toxin -
- 2713980..2714164 - 185 NuclAT_9 - Antitoxin
- 2714021..2714164 - 144 NuclAT_11 - -
DOU32_RS13860 2714166..2714306 + 141 WP_073340360.1 putative holin-like toxin Toxin
- 2714239..2714440 - 202 NuclAT_7 - -
DOU32_RS13865 2714537..2714680 + 144 WP_073437820.1 putative holin-like toxin -
- 2714612..2714874 - 263 NuclAT_10 - -
- 2714824..2714873 + 50 NuclAT_13 - -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-46)


Sequences


Toxin        


Download         Length: 47 a.a.        Molecular weight: 5218.33 Da        Isoelectric Point: 10.3265

>T106934 WP_073340360.1 NZ_CP030045:2714166-2714306 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 141 bp

>T106934 NZ_CP030045:2714166-2714306 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 185 bp

>AT106934 NZ_CP030045:c2714164-2713980 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3N3Z2N6


Antitoxin

Download structure file

References