Detailed information of TA system TA106927

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2613949..2614211
• Replicon: chromosome
• Accession: NZ_CP030045
• Organism: Enterococcus faecalis strain C54

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DOU32_RS13370
• Protein ID: WP_002367458.1
• Coordinates: 2614068..2614211 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2613949..2614135 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOU32_RS13355	2609407..2612150	+	2744	Protein_2460	glycoside hydrolase family 65 protein	-
DOU32_RS13360	2612165..2612815	+	651	WP_002389419.1	beta-phosphoglucomutase	-
DOU32_RS13365	2613235..2613828	+	594	WP_002389391.1	hypothetical protein	-
-	2613949..2614094	+	146	NuclAT_12	-	-
-	2613949..2614135	+	187	NuclAT_8	-	Antitoxin
DOU32_RS13370	2614068..2614211	-	144	WP_002367458.1	putative holin-like toxin	Toxin
DOU32_RS13375	2614443..2615414	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
DOU32_RS13380	2615589..2616026	-	438	WP_002389480.1	peptide-methionine (R)-S-oxide reductase MsrB	-
DOU32_RS13385	2616159..2616713	-	555	WP_002389433.1	septum formation protein Maf	-
DOU32_RS13390	2616738..2618870	-	2133	WP_138818642.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5311.50 Da
• Isoelectric Point: 10.8331

>T106927 WP_002367458.1 NZ_CP030045:c2614211-2614068 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T106927 NZ_CP030045:c2614211-2614068 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 187 bp

>AT106927 NZ_CP030045:2613949-2614135 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin