Detailed information of TA system TA106923

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2544489..2544775
• Replicon: chromosome
• Accession: NZ_CP030045
• Organism: Enterococcus faecalis strain C54

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DOU32_RS13030
• Protein ID: WP_002393909.1
• Coordinates: 2544647..2544775 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2544489..2544698 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOU32_RS13000	2539742..2540695	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
DOU32_RS13005	2540734..2541489	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
DOU32_RS13010	2541486..2542451	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
DOU32_RS13015	2542448..2543395	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
DOU32_RS13020	2543580..2544032	+	453	WP_002389410.1	YueI family protein	-
-	2544058..2544265	+	208	NuclAT_2	-	-
-	2544095..2544269	+	175	NuclAT_5	-	-
DOU32_RS13025	2544214..2544341	-	128	Protein_2397	putative holin-like toxin	-
-	2544489..2544698	+	210	NuclAT_3	-	Antitoxin
-	2544523..2544702	+	180	NuclAT_4	-	-
DOU32_RS13030	2544647..2544775	-	129	WP_002393909.1	hypothetical protein	Toxin
DOU32_RS13035	2544938..2547208	-	2271	WP_002389492.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
DOU32_RS13040	2547379..2547879	+	501	WP_002372831.1	cysteine hydrolase	-
DOU32_RS13050	2548278..2549174	+	897	WP_002389477.1	YitT family protein	-
DOU32_RS13055	2549225..2549623	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T106923 WP_002393909.1 NZ_CP030045:c2544775-2544647 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T106923 NZ_CP030045:c2544775-2544647 [Enterococcus faecalis]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 210 bp

>AT106923 NZ_CP030045:2544489-2544698 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin