Detailed information of TA system TA106919

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-RNAII/Fst(toxin)
• Location: 43614..43856
• Replicon: plasmid pC25-1
• Accession: NZ_CP030043
• Organism: Enterococcus faecalis strain C25

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: DOU31_RS14625
• Protein ID: WP_002360667.1
• Coordinates: 43614..43724 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	43765..43856 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOU31_RS14585	39525..40145	+	621	WP_161978277.1	recombinase family protein	-
DOU31_RS14590	40135..40449	+	315	WP_002390465.1	hypothetical protein	-
DOU31_RS14595	40443..40667	+	225	WP_002358271.1	hypothetical protein	-
DOU31_RS14600	40736..40936	+	201	WP_002390466.1	hypothetical protein	-
DOU31_RS14605	40957..41259	+	303	WP_128713120.1	hypothetical protein	-
DOU31_RS14610	41688..43016	+	1329	WP_138807346.1	Y-family DNA polymerase	-
DOU31_RS14615	43013..43363	+	351	WP_138807348.1	UvaF	-
DOU31_RS14625	43614..43724	+	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	43765..43856	-	92	NuclAT_0	-	Antitoxin
-	43765..43856	-	92	NuclAT_0	-	Antitoxin
-	43765..43856	-	92	NuclAT_0	-	Antitoxin
-	43765..43856	-	92	NuclAT_0	-	Antitoxin
DOU31_RS14630	43965..44261	+	297	WP_002360665.1	replication control protein PrgN	-
DOU31_RS14635	44515..45297	+	783	WP_002360664.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	erm(A) / optrA / fexA	-	1..45581	45581

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T106919 WP_002360667.1 NZ_CP030043:43614-43724 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T106919 NZ_CP030043:43614-43724 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin

Nucleotide

• Length: 92 bp

>AT106919 NZ_CP030043:c43856-43765 [Enterococcus faecalis]
TAAAAATATGTTATACTAAAGGTGCGAAACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGA
TTGCTTTTTTTT

Structures

Antitoxin