Detailed information of TA system TA106910

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 259979..260231
• Replicon: chromosome
• Accession: NZ_CP030042
• Organism: Enterococcus faecalis strain C25

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DOU31_RS01275
• Protein ID: WP_002393909.1
• Coordinates: 259979..260107 (+)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	260052..260231 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOU31_RS01255	255227..255625	+	399	WP_002354951.1	glyoxalase	-
DOU31_RS01255	255227..255625	+	399	WP_002354951.1	glyoxalase	-
DOU31_RS01260	255676..256572	-	897	WP_002354953.1	YitT family protein	-
DOU31_RS01260	255676..256572	-	897	WP_002354953.1	YitT family protein	-
DOU31_RS01265	256875..257375	-	501	WP_002365352.1	cysteine hydrolase	-
DOU31_RS01265	256875..257375	-	501	WP_002365352.1	cysteine hydrolase	-
DOU31_RS01270	257546..259816	+	2271	WP_002398160.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
DOU31_RS01270	257546..259816	+	2271	WP_002398160.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
DOU31_RS01275	259979..260107	+	129	WP_002393909.1	hypothetical protein	Toxin
DOU31_RS01275	259979..260107	+	129	WP_002393909.1	hypothetical protein	Toxin
-	260052..260231	-	180	-	-	Antitoxin
DOU31_RS01280	260413..260540	+	128	Protein_225	putative holin-like toxin	-
DOU31_RS01280	260413..260540	+	128	Protein_225	putative holin-like toxin	-
DOU31_RS01285	260725..261177	-	453	WP_002354958.1	YueI family protein	-
DOU31_RS01285	260725..261177	-	453	WP_002354958.1	YueI family protein	-
DOU31_RS01290	261362..262309	+	948	WP_010716775.1	iron chelate uptake ABC transporter family permease subunit	-
DOU31_RS01290	261362..262309	+	948	WP_010716775.1	iron chelate uptake ABC transporter family permease subunit	-
DOU31_RS01295	262306..263271	+	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
DOU31_RS01295	262306..263271	+	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
DOU31_RS01300	263268..264023	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
DOU31_RS01300	263268..264023	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
DOU31_RS01305	264062..265015	+	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
DOU31_RS01305	264062..265015	+	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T106910 WP_002393909.1 NZ_CP030042:259979-260107 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T106910 NZ_CP030042:259979-260107 [Enterococcus faecalis]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT106910 NZ_CP030042:c260231-260052 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin