Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 191610..191872 Replicon chromosome
Accession NZ_CP030042
Organism Enterococcus faecalis strain C25

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag DOU31_RS00925 Protein ID WP_002392696.1
Coordinates 191610..191753 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 191686..191872 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOU31_RS00905 186951..189083 + 2133 WP_010716772.1 DNA mismatch repair endonuclease MutL -
DOU31_RS00910 189108..189662 + 555 WP_002354869.1 septum formation protein Maf -
DOU31_RS00915 189795..190232 + 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
DOU31_RS00920 190407..191378 + 972 WP_002381060.1 ribose-phosphate diphosphokinase -
DOU31_RS00925 191610..191753 + 144 WP_002392696.1 putative holin-like toxin Toxin
- 191686..191872 - 187 - - Antitoxin
DOU31_RS00935 191993..192586 - 594 WP_002398183.1 hypothetical protein -
DOU31_RS00940 193048..193698 - 651 WP_002398182.1 beta-phosphoglucomutase -
DOU31_RS00945 193713..196457 - 2745 WP_025189669.1 glycoside hydrolase family 65 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T106906 WP_002392696.1 NZ_CP030042:191610-191753 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

>T106906 NZ_CP030042:191610-191753 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 187 bp

>AT106906 NZ_CP030042:c191872-191686 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACCAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References