Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 108540..108927 Replicon chromosome
Accession NZ_CP030042
Organism Enterococcus faecalis strain C25

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag DOU31_RS00540 Protein ID WP_002396786.1
Coordinates 108540..108683 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 108794..108927 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOU31_RS15125 105287..108346 + 3060 WP_002398514.1 WxL domain-containing protein -
DOU31_RS00540 108540..108683 - 144 WP_002396786.1 putative holin-like toxin Toxin
- 108794..108927 + 134 - - Antitoxin
DOU31_RS00545 109278..113057 + 3780 WP_010818049.1 WxL domain-containing protein -
- 113059..113314 + 256 - - -
- 113247..113399 - 153 - - -
DOU31_RS00550 113247..113399 - 153 WP_138807026.1 putative holin-like toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T106901 WP_002396786.1 NZ_CP030042:c108683-108540 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T106901 NZ_CP030042:c108683-108540 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 134 bp

>AT106901 NZ_CP030042:108794-108927 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCCGT
TATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References