Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2041874..2042393 Replicon chromosome
Accession NZ_CP030023
Organism Streptococcus suis strain ISU2414

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag DK877_RS10115 Protein ID WP_013730620.1
Coordinates 2041874..2042131 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag DK877_RS10120 Protein ID WP_002939010.1
Coordinates 2042133..2042393 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK877_RS10100 2038345..2040075 - 1731 WP_009910905.1 membrane protein -
DK877_RS10105 2040438..2041346 - 909 WP_074411269.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
DK877_RS10110 2041330..2041860 - 531 WP_009910909.1 DUF1697 domain-containing protein -
DK877_RS10115 2041874..2042131 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
DK877_RS10120 2042133..2042393 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DK877_RS10125 2042469..2042924 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
DK877_RS10130 2042928..2043296 - 369 WP_013730622.1 hypothetical protein -
DK877_RS10135 2043289..2043858 - 570 WP_022540720.1 ribonuclease M5 -
DK877_RS10140 2043842..2044624 - 783 WP_002939015.1 TatD family hydrolase -
DK877_RS10145 2044732..2044869 - 138 WP_002939016.1 50S ribosomal protein L34 -
DK877_RS10150 2045037..2046032 - 996 WP_013730624.1 protein jag -
DK877_RS10155 2046052..2046864 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
DK877_RS10160 2046848..2047207 - 360 WP_013730625.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T106883 WP_013730620.1 NZ_CP030023:c2042131-2041874 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T106883 NZ_CP030023:c2042131-2041874 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT106883 WP_002939010.1 NZ_CP030023:c2042393-2042133 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT106883 NZ_CP030023:c2042393-2042133 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References