Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 225051..225570 Replicon chromosome
Accession NZ_CP030020
Organism Streptococcus suis strain ISU2514

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8M4E9
Locus tag DK875_RS01265 Protein ID WP_002939009.1
Coordinates 225313..225570 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag DK875_RS01260 Protein ID WP_002939010.1
Coordinates 225051..225311 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK875_RS01220 220236..220595 + 360 WP_004194560.1 ribonuclease P protein component -
DK875_RS01225 220579..221391 + 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
DK875_RS01230 221411..222406 + 996 WP_013730624.1 protein jag -
DK875_RS01235 222574..222711 + 138 WP_002939016.1 50S ribosomal protein L34 -
DK875_RS01240 222820..223602 + 783 WP_002939015.1 TatD family hydrolase -
DK875_RS01245 223565..224155 + 591 WP_002939014.1 ribonuclease M5 -
DK875_RS01250 224148..224516 + 369 WP_002939013.1 hypothetical protein -
DK875_RS01255 224520..224975 + 456 WP_002939012.1 8-oxo-dGTP diphosphatase -
DK875_RS01260 225051..225311 + 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DK875_RS01265 225313..225570 + 258 WP_002939009.1 Txe/YoeB family addiction module toxin Toxin
DK875_RS01270 225584..226114 + 531 WP_002939008.1 DUF1697 domain-containing protein -
DK875_RS01275 226098..227006 + 909 WP_074390583.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
DK875_RS01280 227209..228939 + 1731 WP_024390921.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10321.83 Da        Isoelectric Point: 7.3119

>T106864 WP_002939009.1 NZ_CP030020:225313-225570 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEVDKLYILSL
KDHYG

Download         Length: 258 bp

>T106864 NZ_CP030020:225313-225570 [Streptococcus suis]
ATGGGAATCCATTTTACAGAGGATGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTCAAGCGAAT
CAATAAGATTATCAAGGATATGCAACGACATCCTTTTGAAGGCATTGCCAAACCAGAACCCTTGAAGTATGATTATCAGG
GTGCCTGGTCTCGGAGAATTGATGCCGAAAATCGGCTGATTTATATGGTAGAAGTAGATAAGCTGTATATTTTGTCTTTA
AAGGATCATTATGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT106864 WP_002939010.1 NZ_CP030020:225051-225311 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT106864 NZ_CP030020:225051-225311 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8M4E9

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References