Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 227090..227677 Replicon chromosome
Accession NZ_CP029843
Organism Lysobacter maris strain HZ9B

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C9I47_RS01030 Protein ID WP_111265082.1
Coordinates 227090..227368 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C9I47_RS01035 Protein ID WP_111267886.1
Coordinates 227378..227677 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9I47_RS01010 223414..224004 + 591 WP_111267884.1 superoxide dismutase family protein -
C9I47_RS01015 224013..224528 + 516 WP_111265080.1 GNAT family N-acetyltransferase -
C9I47_RS01020 224646..225554 - 909 WP_111267885.1 hypothetical protein -
C9I47_RS01025 225764..227041 + 1278 WP_111265081.1 acetyl-CoA C-acetyltransferase -
C9I47_RS01030 227090..227368 + 279 WP_111265082.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C9I47_RS01035 227378..227677 + 300 WP_111267886.1 HigA family addiction module antidote protein Antitoxin
C9I47_RS01040 227783..228160 - 378 WP_111265083.1 VOC family protein -
C9I47_RS01045 228196..229443 - 1248 WP_111265084.1 heme biosynthesis protein HemY -
C9I47_RS01050 229440..230498 - 1059 WP_111265085.1 uroporphyrinogen-III C-methyltransferase -
C9I47_RS01055 230580..231347 - 768 WP_111265086.1 uroporphyrinogen-III synthase -
C9I47_RS01060 231490..231990 + 501 WP_111265087.1 YiiD C-terminal domain-containing protein -
C9I47_RS01065 232075..232482 + 408 WP_170288234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10834.36 Da        Isoelectric Point: 9.4790

>T106748 WP_111265082.1 NZ_CP029843:227090-227368 [Lysobacter maris]
MIRSFRCMDTQRLFESGKCRRFSAIARIATRKLVQLDAAHTLDFLRAPPGNRLEALRGDRRGQHSIRINDQFRLCFRWTD
DGPEDVEIVDYH

Download         Length: 279 bp

>T106748 NZ_CP029843:227090-227368 [Lysobacter maris]
ATGATACGCAGCTTCCGGTGCATGGATACGCAACGGTTGTTCGAGAGCGGAAAGTGCCGTCGTTTCAGCGCGATCGCCAG
GATTGCCACACGCAAGCTGGTCCAGCTGGACGCGGCGCACACGCTGGACTTTCTGCGCGCACCGCCGGGCAATCGGCTCG
AGGCCCTGCGGGGCGACCGTCGGGGTCAGCACAGCATCCGGATCAACGATCAGTTCCGGCTGTGCTTCCGCTGGACCGAC
GATGGACCGGAAGACGTGGAGATCGTCGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11294.00 Da        Isoelectric Point: 9.7336

>AT106748 WP_111267886.1 NZ_CP029843:227378-227677 [Lysobacter maris]
MFKNGMRPVHPGEILREDYLVPLELSANALARRLHVPAPRINDIVRERRGISADTAMRLARYFGGDARSWLDLQAAYDLR
VAEIENLRRIEREITPAAA

Download         Length: 300 bp

>AT106748 NZ_CP029843:227378-227677 [Lysobacter maris]
ATGTTCAAGAACGGCATGCGGCCGGTACACCCCGGCGAGATTCTGCGCGAGGACTACCTGGTGCCCCTTGAGCTGAGCGC
GAACGCGCTGGCGCGACGGCTGCATGTGCCGGCGCCGCGGATCAACGACATCGTGCGCGAACGTCGGGGCATTTCCGCCG
ATACGGCGATGCGTCTGGCGCGCTACTTCGGCGGGGACGCGCGCTCGTGGCTCGATCTACAGGCCGCCTATGACCTGCGG
GTGGCCGAGATCGAGAACCTGCGGCGGATCGAACGCGAGATCACCCCCGCCGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References