Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2564828..2565421 Replicon chromosome
Accession NZ_CP029825
Organism Burkholderia sp. JP2-270

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DM992_RS29700 Protein ID WP_111019778.1
Coordinates 2565143..2565421 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DM992_RS29695 Protein ID WP_034185116.1
Coordinates 2564828..2565130 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM992_RS41915 2559887..2560030 + 144 WP_162631763.1 hypothetical protein -
DM992_RS29670 2560100..2561371 + 1272 WP_111020468.1 Rieske 2Fe-2S domain-containing protein -
DM992_RS29675 2561386..2561862 + 477 WP_014900133.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
DM992_RS29680 2561880..2562206 + 327 WP_111019775.1 non-heme iron oxygenase ferredoxin subunit -
DM992_RS29685 2562196..2563416 + 1221 WP_111019776.1 FAD-dependent oxidoreductase -
DM992_RS29690 2563508..2564794 + 1287 WP_111019777.1 DUF445 domain-containing protein -
DM992_RS29695 2564828..2565130 - 303 WP_034185116.1 HigA family addiction module antidote protein Antitoxin
DM992_RS29700 2565143..2565421 - 279 WP_111019778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM992_RS29710 2565810..2567450 + 1641 WP_111019779.1 acetolactate synthase large subunit -
DM992_RS29715 2567480..2568913 + 1434 WP_111019780.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10529.95 Da        Isoelectric Point: 7.9177

>T106740 WP_111019778.1 NZ_CP029825:c2565421-2565143 [Burkholderia sp. JP2-270]
MIHSFRCKVTQSLFAGESPGRFRAIETVATRKLQMVAAAKELRDLRAPPGNRLEALHGDREGQHGIRINDRWRICFEWTD
DGPANVEIVDYH

Download         Length: 279 bp

>T106740 NZ_CP029825:c2565421-2565143 [Burkholderia sp. JP2-270]
ATGATCCACTCCTTCCGATGCAAGGTCACGCAGTCGCTGTTCGCCGGAGAATCGCCCGGGCGCTTTCGCGCAATCGAAAC
CGTTGCAACCCGCAAACTGCAAATGGTCGCCGCCGCGAAAGAGCTGCGCGATTTGCGGGCGCCTCCCGGCAACCGGCTCG
AAGCACTGCATGGCGATCGGGAAGGCCAGCACGGCATCCGCATCAACGACCGATGGCGGATCTGCTTCGAATGGACCGAC
GACGGCCCCGCCAACGTCGAGATCGTCGACTATCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11570.36 Da        Isoelectric Point: 8.5562

>AT106740 WP_034185116.1 NZ_CP029825:c2565130-2564828 [Burkholderia sp. JP2-270]
MLKNGMRPIHPGEILREEFLVPLEMSVNALALALNVPATRLHEIVKERRGITADTAYRLARYFDTSPEFWLNLQAAYDLK
TLPTRSEIDRKVEPRERTHA

Download         Length: 303 bp

>AT106740 NZ_CP029825:c2565130-2564828 [Burkholderia sp. JP2-270]
ATGCTCAAGAACGGAATGCGCCCGATTCATCCGGGTGAAATCCTGCGGGAAGAATTCCTCGTCCCGCTGGAAATGAGCGT
CAACGCGCTGGCGCTCGCGTTGAACGTGCCGGCCACGCGCCTGCACGAAATCGTCAAGGAACGGCGTGGAATCACGGCCG
ATACGGCTTACCGGCTCGCGCGCTACTTCGATACGTCGCCGGAATTCTGGCTTAACCTGCAAGCCGCTTACGATCTCAAG
ACGCTACCCACGCGCAGCGAGATCGACCGCAAGGTCGAACCGCGCGAACGCACGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References