Detailed information of TA system TA106733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 4486649..4487184
• Replicon: chromosome
• Accession: NZ_CP029823
• Organism: Streptomyces malaysiensis strain DSM 4137

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: L1KUL2
• Locus tag: DNK48_RS17925
• Protein ID: WP_009321768.1
• Coordinates: 4486649..4486903 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: DNK48_RS17930
• Protein ID: WP_099014855.1
• Coordinates: 4486900..4487184 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DNK48_RS17905	4482613..4483536	-	924	WP_159033460.1	sugar nucleotide-binding protein	-
DNK48_RS17910	4483649..4484731	+	1083	WP_099014858.1	alcohol dehydrogenase catalytic domain-containing protein	-
DNK48_RS17915	4484785..4485510	+	726	WP_186000366.1	HAD family phosphatase	-
DNK48_RS17920	4486059..4486442	+	384	WP_099014856.1	hypothetical protein	-
DNK48_RS17925	4486649..4486903	-	255	WP_009321768.1	Txe/YoeB family addiction module toxin	Toxin
DNK48_RS17930	4486900..4487184	-	285	WP_099014855.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
DNK48_RS43890	4487503..4487667	-	165	WP_159033459.1	hypothetical protein	-
DNK48_RS17935	4487955..4488740	-	786	WP_069864458.1	hypothetical protein	-
DNK48_RS17940	4489089..4490432	+	1344	WP_099014854.1	recombinase	-
DNK48_RS17945	4490547..4491200	+	654	WP_107528525.1	winged helix-turn-helix domain-containing protein	-
DNK48_RS17950	4491195..4491863	-	669	WP_107528561.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-65)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10098.61 Da
• Isoelectric Point: 8.4390

>T106733 WP_009321768.1 NZ_CP029823:c4486903-4486649 [Streptomyces malaysiensis]
VRLVFEDQGWEDYTSWLKNDRKMLARINKLIEDVKRDPFTGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY

Nucleotide

• Length: 255 bp

>T106733 NZ_CP029823:c4486903-4486649 [Streptomyces malaysiensis]
GTGAGGCTTGTCTTCGAGGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGATCGCAAGATGCTGGCCCGGAT
CAATAAGCTCATCGAGGATGTCAAGCGCGACCCCTTCACGGGGATCGGCAAGCCTGAGCCGCTGAAGTACCACTTGCCCG
GAGCGTGGTCGAGGCGGATCGATGACGAGCACCGCCTTGTCTACTTGGTCACGGACAAGGAGATCGTGATCCTCGCGGCT
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10227.50 Da
• Isoelectric Point: 5.1514

>AT106733 WP_099014855.1 NZ_CP029823:c4487184-4486900 [Streptomyces malaysiensis]
MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALAHIDVSEREL
IDPDSPDAAGERAA

Nucleotide

• Length: 285 bp

>AT106733 NZ_CP029823:c4487184-4486900 [Streptomyces malaysiensis]
ATGTCCATAACTGCGAGCGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACGATCACGAGGCCATCGA
GATCGTCTCGAAGCACGGCAATGCCGTGCTCGTCTCGGCCGAGGACTATGCGGCATTGCGCGAAGGCTCGTACCTGCTGC
GCTCTCCGGCGAACGCTCGCCGACTGCTCAAAGCGTACGAGAACGCCCTGGCCCACATCGACGTGTCAGAGCGAGAGCTG
ATCGACCCCGACTCGCCGGATGCGGCCGGTGAGAGGGCTGCGTGA

Structures

Toxin

• AlphaFold DB: A0A540PPG9