Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 73050..73707 Replicon plasmid pR16.0676_90k
Accession NZ_CP029802
Organism Salmonella enterica subsp. enterica serovar Anatum strain R16.0676

Toxin (Protein)


Gene name higB Uniprot ID U3PDC3
Locus tag DNA64_RS24485 Protein ID WP_000270043.1
Coordinates 73050..73400 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DNA64_RS24490 Protein ID WP_000124640.1
Coordinates 73405..73707 (+) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DNA64_RS24435 68361..68540 + 180 Protein_85 helix-turn-helix transcriptional regulator -
DNA64_RS24440 68605..69309 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
DNA64_RS24445 69524..70021 - 498 WP_000062185.1 hypothetical protein -
DNA64_RS24450 70024..70512 - 489 WP_001273096.1 DUF1643 domain-containing protein -
DNA64_RS24455 70609..70944 + 336 WP_000683476.1 hypothetical protein -
DNA64_RS24460 70959..71429 - 471 WP_001281821.1 hypothetical protein -
DNA64_RS24465 71422..71793 - 372 WP_000516916.1 hypothetical protein -
DNA64_RS24470 71804..71998 - 195 WP_000343597.1 hypothetical protein -
DNA64_RS24480 72339..72887 - 549 WP_001061574.1 transcriptional regulator -
DNA64_RS24485 73050..73400 + 351 WP_000270043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DNA64_RS24490 73405..73707 + 303 WP_000124640.1 XRE family transcriptional regulator Antitoxin
DNA64_RS24495 73734..74027 - 294 WP_001239997.1 chromosome segregation protein ParM -
DNA64_RS24500 74115..74387 - 273 WP_001043047.1 HU family DNA-binding protein -
DNA64_RS24505 74445..74972 - 528 WP_001236377.1 thermonuclease family protein -
DNA64_RS24515 75203..76060 - 858 WP_001167032.1 hypothetical protein -
DNA64_RS24520 76047..76277 - 231 WP_000972663.1 hypothetical protein -
DNA64_RS24525 76277..76795 - 519 WP_000210756.1 nitrite reductase -
DNA64_RS24530 76792..77238 - 447 WP_000919345.1 Fe3+-siderophore ABC transporter permease -
DNA64_RS24535 77238..77597 - 360 WP_000422768.1 hypothetical protein -
DNA64_RS24540 77654..78082 - 429 WP_000591074.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..90137 90137


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-117)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 15014.38 Da        Isoelectric Point: 12.8644

>T106729 WP_000270043.1 NZ_CP029802:73050-73400 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 351 bp

>T106729 NZ_CP029802:73050-73400 [Salmonella enterica subsp. enterica serovar Anatum]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 12963.60 Da        Isoelectric Point: 12.8000

>AT106729 WP_000124640.1 NZ_CP029802:73405-73707 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK

Download         Length: 303 bp

>AT106729 NZ_CP029802:73405-73707 [Salmonella enterica subsp. enterica serovar Anatum]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7G8AFB9


Antitoxin

Source ID Structure

References