Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2577405..2577928 Replicon chromosome
Accession NZ_CP029751
Organism Staphylococcus aureus strain Smith

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag CFC57_RS13300 Protein ID WP_000074048.1
Coordinates 2577405..2577671 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag CFC57_RS13305 Protein ID WP_000587617.1
Coordinates 2577671..2577928 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFC57_RS13280 2572615..2573802 - 1188 WP_000026195.1 MFS transporter -
CFC57_RS13285 2574197..2574973 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
CFC57_RS13290 2574966..2575628 - 663 WP_115287584.1 ATP-binding cassette domain-containing protein -
CFC57_RS13295 2575973..2577049 - 1077 WP_001076675.1 M42 family metallopeptidase -
CFC57_RS13300 2577405..2577671 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
CFC57_RS13305 2577671..2577928 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CFC57_RS13310 2578287..2578742 + 456 WP_000732082.1 DUF1307 domain-containing protein -
CFC57_RS13315 2578910..2580487 - 1578 WP_000143506.1 FMN-binding glutamate synthase family protein -
CFC57_RS13320 2580681..2581430 + 750 WP_000072456.1 CPBP family intramembrane metalloprotease -
CFC57_RS13325 2581654..2582847 - 1194 WP_000675398.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T106722 WP_000074048.1 NZ_CP029751:c2577671-2577405 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T106722 NZ_CP029751:c2577671-2577405 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT106722 WP_000587617.1 NZ_CP029751:c2577928-2577671 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT106722 NZ_CP029751:c2577928-2577671 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References