Detailed information of TA system TA106714

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2076301..2076608
• Replicon: chromosome
• Accession: NZ_CP029751
• Organism: Staphylococcus aureus strain Smith

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: CFC57_RS10625
• Protein ID: WP_072357969.1
• Coordinates: 2076432..2076608 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2076301..2076440 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFC57_RS10585	2071692..2071952	+	261	WP_001791826.1	hypothetical protein	-
CFC57_RS10590	2072005..2072355	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CFC57_RS10595	2073038..2073487	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
CFC57_RS10600	2073582..2073916	-	335	Protein_2007	SH3 domain-containing protein	-
CFC57_RS10605	2074517..2075008	-	492	WP_000920038.1	staphylokinase	-
CFC57_RS10610	2075199..2075954	-	756	WP_000861038.1	CHAP domain-containing protein	-
CFC57_RS10615	2075966..2076220	-	255	WP_000611512.1	phage holin	-
CFC57_RS10620	2076272..2076379	+	108	WP_031762631.1	hypothetical protein	-
-	2076301..2076440	+	140	NuclAT_0	-	Antitoxin
-	2076301..2076440	+	140	NuclAT_0	-	Antitoxin
-	2076301..2076440	+	140	NuclAT_0	-	Antitoxin
-	2076301..2076440	+	140	NuclAT_0	-	Antitoxin
CFC57_RS10625	2076432..2076608	-	177	WP_072357969.1	putative holin-like toxin	Toxin
CFC57_RS10630	2076751..2077125	-	375	WP_000340977.1	hypothetical protein	-
CFC57_RS10635	2077181..2077468	-	288	WP_115287551.1	hypothetical protein	-
CFC57_RS10640	2077515..2077667	-	153	WP_001153681.1	hypothetical protein	-
CFC57_RS10645	2077657..2081442	-	3786	WP_000582186.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / tsst-1 / groEL	2072005..2145409	73404

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T106714 WP_072357969.1 NZ_CP029751:c2076608-2076432 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106714 NZ_CP029751:c2076608-2076432 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT106714 NZ_CP029751:2076301-2076440 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin