Detailed information of TA system TA106711

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 381733..382040
• Replicon: chromosome
• Accession: NZ_CP029751
• Organism: Staphylococcus aureus strain Smith

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CFC57_RS02015
• Protein ID: WP_011447039.1
• Coordinates: 381733..381909 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	381899..382040 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFC57_RS01995	376968..380753	+	3786	WP_000582186.1	hypothetical protein	-
CFC57_RS02000	380743..380895	+	153	WP_001153681.1	hypothetical protein	-
CFC57_RS02005	380942..381229	+	288	WP_001040254.1	hypothetical protein	-
CFC57_RS02010	381287..381583	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
CFC57_RS02015	381733..381909	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	381899..382040	-	142	-	-	Antitoxin
CFC57_RS02025	382121..382375	+	255	WP_000611512.1	phage holin	-
CFC57_RS02030	382387..383142	+	756	WP_000861038.1	CHAP domain-containing protein	-
CFC57_RS02035	384040..384867	-	828	WP_000136019.1	alpha/beta hydrolase	-
CFC57_RS02040	384940..386139	-	1200	WP_000286475.1	NADH-dependent flavin oxidoreductase	-
CFC57_RS02045	386235..386327	+	93	WP_031873253.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	341964..383142	41178

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106711 WP_011447039.1 NZ_CP029751:381733-381909 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106711 NZ_CP029751:381733-381909 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 142 bp

>AT106711 NZ_CP029751:c382040-381899 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin