Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3819997..3820796 Replicon chromosome
Accession NZ_CP029747
Organism Escherichia coli strain 2016C-3878

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag BEN53_RS19395 Protein ID WP_000347273.1
Coordinates 3820332..3820796 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag BEN53_RS19390 Protein ID WP_001308975.1
Coordinates 3819997..3820332 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEN53_RS19375 3815782..3816552 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
BEN53_RS19380 3816568..3817902 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
BEN53_RS19385 3818277..3819848 + 1572 WP_001273756.1 galactarate dehydratase -
BEN53_RS19390 3819997..3820332 + 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
BEN53_RS19395 3820332..3820796 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
BEN53_RS19400 3820851..3821660 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
BEN53_RS19410 3821909..3823189 + 1281 WP_000681961.1 tagatose-bisphosphate aldolase subunit KbaZ -
BEN53_RS19415 3823212..3823685 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
BEN53_RS19420 3823696..3824475 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
BEN53_RS19425 3824465..3825343 + 879 WP_001298314.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
BEN53_RS19430 3825361..3825795 + 435 WP_000948834.1 PTS sugar transporter subunit IIA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T106690 WP_000347273.1 NZ_CP029747:3820332-3820796 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T106690 NZ_CP029747:3820332-3820796 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT106690 WP_001308975.1 NZ_CP029747:3819997-3820332 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT106690 NZ_CP029747:3819997-3820332 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SSH7


Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References