Detailed information of TA system TA106655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3202607..3203260
• Replicon: chromosome
• Accession: NZ_CP029746
• Organism: Serratia marcescens strain AR_0122

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AM369_RS15025
• Protein ID: WP_033645671.1
• Coordinates: 3202607..3202957 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A5C7DBM3
• Locus tag: AM369_RS15030
• Protein ID: WP_019453270.1
• Coordinates: 3202961..3203260 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM369_RS14995	3197869..3198558	-	690	WP_033648575.1	trehalose-6-phosphate synthase	-
AM369_RS15000	3198572..3198982	-	411	WP_033648574.1	GNAT family N-acetyltransferase	-
AM369_RS15005	3199012..3200382	-	1371	WP_033648572.1	glutamine synthetase family protein	-
AM369_RS15010	3200628..3200945	+	318	WP_041037744.1	hypothetical protein	-
AM369_RS15015	3200936..3201331	-	396	WP_033648570.1	hypothetical protein	-
AM369_RS15020	3201331..3202335	-	1005	WP_043148198.1	hypothetical protein	-
AM369_RS15025	3202607..3202957	+	351	WP_033645671.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM369_RS15030	3202961..3203260	+	300	WP_019453270.1	XRE family transcriptional regulator	Antitoxin
AM369_RS15035	3203250..3204167	-	918	WP_033648568.1	LysR family transcriptional regulator	-
AM369_RS15040	3204336..3205034	+	699	WP_033648567.1	CoA transferase subunit A	-
AM369_RS15045	3205046..3205699	+	654	WP_033648566.1	CoA transferase subunit B	-
AM369_RS15050	3205713..3206897	+	1185	WP_033648565.1	acetyl-CoA C-acetyltransferase	-
AM369_RS15055	3206916..3207839	+	924	WP_033648563.1	3-hydroxyacyl-CoA dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-83)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13546.81 Da
• Isoelectric Point: 8.2699

>T106655 WP_033645671.1 NZ_CP029746:3202607-3202957 [Serratia marcescens]
MWTVMTTEEFDRWLCEQDESTQEKVLAALVMLERAGPSLRRPFVDVLKGSLHPNMKELRIQHKGRPIRAFFAFDPARQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQYLMCYFKE

Nucleotide

• Length: 351 bp

>T106655 NZ_CP029746:3202607-3202957 [Serratia marcescens]
ATGTGGACGGTAATGACAACGGAAGAGTTTGATCGGTGGCTCTGTGAGCAGGATGAATCGACGCAGGAAAAGGTGTTGGC
CGCGCTGGTGATGCTCGAGCGTGCCGGGCCTTCTCTCCGGCGGCCTTTTGTCGACGTGCTGAAAGGTTCGTTGCATCCCA
ACATGAAAGAGCTGCGTATTCAGCACAAAGGGCGGCCGATTCGCGCCTTTTTCGCCTTCGATCCGGCGCGGCAGGCGATT
GTGCTGTGTGCGGGCGACAAAACGGGTAATGAGAAGCGGTTTTATAAAGTGATGCTGCCCATTGCGGATGCGCAGTTCAC
CCAATATTTGATGTGTTATTTCAAGGAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11013.71 Da
• Isoelectric Point: 7.3207

>AT106655 WP_019453270.1 NZ_CP029746:3202961-3203260 [Serratia marcescens]
MSTLKQLLASRTPESRRRIEEMAEEMLFEAHLHQLREALNISQQELAKTLGISQPSVAAIEGRGNELKISTLKRYVEAMG
GTLRLDVELPGGKHVGFTV

Nucleotide

• Length: 300 bp

>AT106655 NZ_CP029746:3202961-3203260 [Serratia marcescens]
ATGAGCACCTTAAAGCAACTGCTGGCCTCCCGCACCCCGGAGAGCCGCCGGCGCATCGAGGAAATGGCCGAAGAGATGCT
GTTTGAAGCGCACCTGCACCAGCTGCGGGAAGCGCTGAATATTTCCCAACAGGAACTGGCGAAAACGCTGGGCATTTCCC
AGCCTTCGGTCGCGGCCATCGAAGGGCGCGGCAACGAGCTGAAGATTTCGACCCTGAAACGCTACGTGGAAGCGATGGGC
GGCACGCTGCGCCTGGACGTTGAGCTGCCGGGCGGCAAGCACGTCGGGTTTACGGTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DBM3