Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1623502..1624154 Replicon chromosome
Accession NZ_CP029746
Organism Serratia marcescens strain AR_0122

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BTF4
Locus tag AM369_RS07690 Protein ID WP_033635775.1
Coordinates 1623502..1623846 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag AM369_RS07695 Protein ID WP_004931828.1
Coordinates 1623852..1624154 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM369_RS07675 1619844..1622102 - 2259 WP_048321906.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
AM369_RS07685 1622323..1623342 + 1020 WP_033649496.1 HTH-type transcriptional regulator GalR -
AM369_RS07690 1623502..1623846 + 345 WP_033635775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM369_RS07695 1623852..1624154 + 303 WP_004931828.1 helix-turn-helix transcriptional regulator Antitoxin
AM369_RS07700 1624182..1625444 - 1263 WP_033649495.1 diaminopimelate decarboxylase -
AM369_RS07705 1625578..1626501 + 924 WP_033649494.1 LysR family transcriptional regulator -
AM369_RS07710 1626529..1627437 - 909 WP_015378928.1 LysR family transcriptional regulator -
AM369_RS07715 1627546..1628430 + 885 WP_048321907.1 MBL fold metallo-hydrolase -
AM369_RS07720 1628499..1629146 + 648 WP_033649493.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13409.48 Da        Isoelectric Point: 10.6087

>T106649 WP_033635775.1 NZ_CP029746:1623502-1623846 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T106649 NZ_CP029746:1623502-1623846 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTGCAGACGTTCGGCCCGCAGTTGACGCGGCCGCATGCCGATACGCTGTATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCGTTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT106649 WP_004931828.1 NZ_CP029746:1623852-1624154 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT106649 NZ_CP029746:1623852-1624154 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCCATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAACACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BTF4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References