Detailed information of TA system TA106582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3628960..3629600
• Replicon: chromosome
• Accession: NZ_CP029738
• Organism: Klebsiella pneumoniae strain AR_0087

Toxin (Protein)

• Gene name: higB
• Uniprot ID: W9BBY1
• Locus tag: AM466_RS18235
• Protein ID: WP_016529833.1
• Coordinates: 3628960..3629307 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AM466_RS18240
• Protein ID: WP_040181955.1
• Coordinates: 3629307..3629600 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM466_RS18225	3624886..3626319	+	1434	WP_002920564.1	glycogen synthase GlgA	-
AM466_RS18230	3626337..3628784	+	2448	WP_002920561.1	glycogen phosphorylase	-
AM466_RS18235	3628960..3629307	+	348	WP_016529833.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM466_RS18240	3629307..3629600	+	294	WP_040181955.1	helix-turn-helix transcriptional regulator	Antitoxin
AM466_RS18245	3629670..3631178	-	1509	WP_023301456.1	glycerol-3-phosphate dehydrogenase	-
AM466_RS18250	3631383..3631712	+	330	WP_002920552.1	thiosulfate sulfurtransferase GlpE	-
AM466_RS18255	3631763..3632593	+	831	WP_024622927.1	rhomboid family intramembrane serine protease GlpG	-
AM466_RS18260	3632643..3633401	+	759	WP_002920548.1	DeoR/GlpR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-87)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13549.56 Da
• Isoelectric Point: 5.6749

>T106582 WP_016529833.1 NZ_CP029738:3628960-3629307 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Nucleotide

• Length: 348 bp

>T106582 NZ_CP029738:3628960-3629307 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10539.30 Da
• Isoelectric Point: 10.1464

>AT106582 WP_040181955.1 NZ_CP029738:3629307-3629600 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV

Nucleotide

• Length: 294 bp

>AT106582 NZ_CP029738:3629307-3629600 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAAGTCTCGTTTAA

Structures

Toxin

• AlphaFold DB: W9BBY1